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Biopharmaceutics – Pharmacokinetics II

(Lectures: 3h/week, Assessment: final exam at the end of each term or September)

  • Variability of in vivo data
  • Repeated dose administration: Non-compartmental analysis
  • Repeated dose administration - One compartment open model: iv bolus, per os administration
  • Single dose administration - Two compartment open model: iv bolus injection
  • Non-oral extravascular administration of drugs
  • Distribution of drugs at specific body tissues
  • Interspecies scaling
  • Pharmacokinetic – Pharmacodynamic modelling: Basic principles
  • Biopharmaceuticals: Pharmacokinetic / Pharmacodynamic issues