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Drug design

(Lectures 3 h/week, Assessment: final exam at the end of each term or September)

  • Lead generation.
  • Lead optimization.
  • Influence of Physicochemical Properties on Drug Action.
  • The concept of lipophilicity.
  • Partition Coefficient. Measurement techniques.
  • Calculation methods.
  • Drug Transport and Lipophilicity.
  • Parabolic model, Bilinear model.
  • Hydrophobic binding. Electronic Interactions.
  • Degree of Ionization.
  • Electronic parameters.
  • Hydrogen bond parameters.
  • Steric Interactions. Steric parameters.
  • Hansch Analysis.
  • Contribution to Drug Design, Pitfalls, Limitations.
  • Stereochemical Aspects in Drug Design.