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 Kourounakis Angeliki 

Associate Professor, Department of Pharmaceutical Chemistry

 

 

Education

  • 1990 B. Pharm, Aristotles University of Thessaloniki.
  • 1995 PhD in Medicinal Chemistry, Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, USA.
  • 1996-1997 Post-doctoral training (Dept. Medicinal Chemistry, Aristotles University of Thessaloniki).
  • 1998-1999 Post-doctoral training ((Division of Medicinal Chemistry, University of Leiden, The Netherlands).

 Research topics

  • Design, synthesis and pharmacological evaluation of bioactive molecules such as  antiinflammatory, antiatherosclerosis and compounds for the prevention or treatment of Alzheimer’s disease – neuronal degeneration. Mechanism of action at the molecular level. Molecular modeling and study of physicochemical properties. Structure-activity relationships. Free radical pharmacochemistry – oxidative stress, prevention thereof. Drug Metabolism – effect of compounds on metabolic enzymes.

List of recent publications

  • Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. Kourounakis AP, Charitos C, Rekka EA, Kourounakis PNJ Med Chem. 2008; 51(18):5861-5

  • EP2306 [2-(4-biphenyl)-4-methyl-octahydro-1,4-benzoxazin-2-ol-hydro-bromide], a novel squalene synthase inhibitor, reduces atherosclerosis in the cholesterol-fed rabbit. Tavridou A, Kaklamanis L, Papalois A, Kourounakis AP, Rekka EA, Kourounakis PN, Charalambous A, Manolopoulos VG. J Pharmacol Exp Ther. 2007; 323(3):794-804.

  • Design and study of some novel ibuprophen derivatives with potential nootropic and neuroprotective properties. I.C. Siskou, E.A. Rekka, A.P. Kourounakis, M.C. Chrysselis, K. Tsiakitzis and P.N. Kourounakis. Bioorg Med Chem. 2007, 15(2):951-61.

  • Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-inflammatory, antioxidant, and hypocholesterolemic properties. Bioorg Med Chem Lett. 2006 16(4):825-9. Doulgkeris CM, Galanakis D, Kourounakis AP et al.

  • Effect of some biologically interesting substituted tetrahydro-1,4-oxazines on drug metabolising enzymes and on inflammation. Rekka EA, Kourounakis AP, Avramidis N, Kourounakis PN. Curr Drug Metab. 2005 6(5):481-5.

  • Stress and active oxygen species--effect of alpha-tocopherol on stress response. Arch Pharm (Weinheim). 2005 338(7):315-21 Tsiakitzis K, Kourounakis AP, Tani E, Rekka EA, Kourounakis PN.

Contact

   
Angeliki Kourounakis
Department  of  Pharmaceutical  Chemistry
School of Pharmacy
University of Athens
Panepistimiopolis,  Zografou
GR – 157 71  Athens, GREECE
Tel./Fax: (3210)7274818
angeliki[at]pharm.uoa[dot]gr
http://amorgos.pharm.auth.gr/angeliki/home.html