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Papanastasiou Ioannis

Assistant Professor, Division of Pharmaceutical Chemistry

Full CV

 

Education

  • 2001 B.S in Pharmacy, Faculty of Pharmacy, National and Kapodistrian University of Athens

  • 2004 M.Sc in Medicinal Chemistry, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens 

  • 2007 Ph.D in Medicinal Chemistry, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens

  • 2008 & 2009 Postdoctoral Researcher Associate, Center for Drug Discovery, Northeastern University, Boston, USA 

  • 2010 – 2014 Postdoctoral research in synthetic pharmaceutical chemistry, Division of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens

Research Interests

  • Design and synthesis of new organic derivatives with pharmacological activity against “Neglected Diseases”, such as trypanosomiasis, leismaniasis and tuberculosis.

 

Recent Publications

  • New hydrazones of 5-nitro-2-furaldehyde with adamantanealkanohydrazides: synthesis and in vitro trypanocidal activity. A.-S Foscolos, I. Papanastasiou, G. B. Foscolos, A. Tsotinis, T. F. Kellici, T. Mavromoustakos, M. C. Taylor, J. M. Kelly. Med.Chem.Comm., 2016, 7, 1229-1236.

  • 4-(1-Adamantyl)phenylalkylamines with Potential Antiproliferative Activity. A. Koperniku, A.-S. Foscolos, I. Papanastasiou, G. B. Foscolos, A. Tsotinis, D. Schols. Lett.Org.Chem., 2016, 13, 171-176.

  • Synthesis and Cytotoxicity of 4-(2-Adamantyl)phenylalkylamines, I. Papanastasiou, S. Riganas, G. B. Foscolos, A. Tsotinis, S. A. Akhtarb, M. A. Khan, K. M. Rahman, D. E. Thurston, Lett.Org.Chem., 2015, 12, 319-323.

  • New aminoadamantane derivatives with antiproliferative activity. I. Papanastasiou, A. Tsotinis, N. Kolocouris, S. P. Nikas, A. Vamvakides, Med.Chem.Res., 2014, 23, 1966–1975

  • Synthesis and trypanocidal action of new adamantane substituted imidazolines. A. Koperniku, I. Papanastasiou, G.B. Foscolos, A. Tsotinis, M.C. Taylor, J.M. Kelly, Med.Chem.Commun., 2013, 4, 856-859.

  • Synthesis, σ1, σ2-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes. S. Riganas, I. Papanastasiou, G. B. Foscolos, G. B, A. Tsotinis, J. J. Bourguignon, G. Serin, J. F. Mirjolet, K. Dimas, V. N. Kourafalos, A. Eleutheriades, V. I. Moutsos, H. Khan, S. Georgakopoulou, A. Zaniou, M. Prassa, M. Theodoropoulou, S. Pondiki, A. Vamvakides. Bioorg. Med. Chem., 2012, 20, 3323-3331.

  • New sigma-receptors binding adamantane phenylalkylamines with anti-cancer activity associated with putative antagonism of neuropathic pain. S. Riganas, I. Papanastasiou, G. B. Foscolos, A. Tsotinis, G. Serin, J. F. Mirjolet, K. Dimas, V. N. Kourafalos, A. Eleutheriades, V. I. Moutsos, H. Khan, S.Georgakopoulou, A. Zaniou, M. Prassa, M. Theodoropoulou, A. Mantelas, S. Pondiki, A. Vamvakides. J.Med.Chem., 2012, 55, 10241-10261.

  • Novel 1',1'-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist. S.P. Nikas, S.O. Alapafuja, I. Papanastasiou, C.A. Paronis, V.G. Shukla, D.P. Papahatjis, A.L. Bowman , A. Halikhedkar , X. Han , A. Makriyannis. J.Med.Chem., 2010, 53(19), 6996-7010.

Contact

Ioannis P. Papanastasiou
School of Health Sciences
Department of Pharmacy
Division of Pharmaceutical Chemistry
National and Kapodistrian University of Athens
Panepistimiopolis - Zografou
Athens -157 84
GREECE
lab. phone: +302107274808
office phone: +302107274828
fax: +302107274747
e-mail: papanastasiou@pharm.uoa. gr