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 Tsotinis Andrew 

 Professor, Department of Pharmaceutical Chemistry




  • Ph D in Synthetic Organic Chemistry. University of London, U.K. (1988). My thesis entitled "Synthetic Studies on Strained Annelated Cyclopropanes" was supervised by Professor P. J. Garratt and involves the study of the synthesis and structural characterisation of polycyclic benzenoid systems.
  • BS major in Chemistry. The University of North Carolina at Charlotte, U.S.A. (1983).


  • 1985-1986     Franz Sondheimer Bursary

  • 1985-1986     Schilizzi Foundation Award 

  • 1986-1987     Franz Sondheimer Bursary

  • 1994             NHRF/Royal Society Award

  • 1995             NHRF/Royal Society Award

 Research topics

  • Development of new synthetic methods.
  • Design and synthesis of organic molecules with pharmacological activity [antineoplastic, antiviral, antibacterial and Central Nervous System (CNS)].
  • Structural modification of bioactive natural products (e.g. melatonin) and their derivatives aiming at the enhancement of their activity and minimization of undesired side effects.

Professional Affiliations

  • Member, Royal Society of Chemistry.

  • Member, Convocation of the University of London.

  • Member, Greek Chemical Society.

  • Secretary General, Division of Pharmacochemistry of the Greek Chemical Society.


 Fellowships - Scholarships

  • DAAD (Germany)                          1996

  • Marie Curie Fellowship (European)   1994

  • CIES (France)                             1993

  • ΙΚΥ (Greece)                               1985-88

 List of recent publications

  • Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines
    Tsotinis A, Vlachou M, Papahatjis DP, et al. J. Med. Chem. 2006, 49 (12), 3509-3519.

  • C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols
    Papahatjis DP, Nahmias VR, Nikas SP, Andreou T, Alapafuja SO, Tsotinis A, et al. J. Med. Chem. 2007, 50 (17), 4048-4060.

  • A new, stereoselective, ring-forming reaction of 1,2-ethanedithiol with N-acylated indoles Tsotinis A, Eleutheriades A, Di Bari L, et al. J. Org. Chem. 2007, 72 (23), 8928-8931.

  • Design, synthesis, and melatoninergic activity of new azido- and isothiocyanato-substituted indoles. Tsotinis A, Afroudakis PA, Davidson K, et al, J. Med. Chem. 2007, 50 (25), 6436-6440.

  • Design, synthesis, and trypanocidal activity of new aminoadamantane derivatives. Papanastasiou I, Tsotinis A, Kolocouris N, et al. J. Med. Chem. 2008, 51 (5), 1496-1500.


Professor Andrew Tsotinis
University of Athens
Faculty of Pharmacy
Department of Pharmaceutical Chemistry
157 71 Athens
Tel.: +30 210 7274812
Fax.: +30 210 7274747
e-mail: tsotinis[at]pharm.uoa[dot]gr