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 Reppas Christos

Professor of Pharmaceutics

FULL CV  

Education

  • 1982    B. Pharm. National and Kapodistrian University of Athens
  • 1986    Ph.D in Pharmaceutics, National and Kapodistrian University of Athens

Teaching

  • Undergraduate courses/labs: Biopharmaceutics and Pharmacokinetics I, Biopharmaceutics and Pharmacokinetics II, Laboratory in Biopharmaceutics and Pharmacokinetics

  • Graduate courses: Advanced Biopharmaceutics and Pharmacokinetics, Applications of Statistics in Pharmaceutical Sciences

Research topics

  • Physiology of the gastrointestinal lumen and its importance to the intralumenal performance of drugs and pharmaceutical dosage forms

  • Effects of the phase of drug (e.g. base vs. salt of base), the type of dosage form and the dosing conditions (fasted vs. fed state) on intralumenal performance and drug absorption

  • Treatment of relevant experimental data, in vitro-in vivo correlations, in vivo (animals) – in vivo (humans) correlations

Distinctions

  • Research Fellow, College of Pharmacy, The University of Michigan, USA (01/1988-07/1989, 06/1990-09/1990) 

  • Visiting Professor, Department of Pharmaceutical Technology, Goethe University, Frankfurt/Main, Germany (5/1998 - 10/1998) 

  • Invited co-editor of issue #7, volume 59 of Advanced Drug Delivery Reviews (2007) 

  • Director of the Laboratory of Biopharmaceutics and Pharmacokinetics of the National and Kapodistrian University of Athens (2007-2010)

  • Member of Editorial Board of AAPS Journal, Journal Pharmacy and Pharmacology, Biopharmaceutics and Drug Disposition (current)

List of recent publications

  • Georgaka D, Butler J, Kesisoglou F, Reppas C, Vertzoni M. Evaluation of Dissolution in the Lower Intestine and Its Impact on the Absorption Process of High Dose Low Solubility Drugs. Mol Pharm. 2017 in press

  • Kourentas A, Vertzoni M, Symillides M, Goumas K, Gibbon R, Butler J, Reppas C. Effectiveness of supersaturation promoting excipients on albendazole concentrations in upper gastrointestinal lumen of fasted healthy adults. Eur J Pharm Sci. 2016 Aug 25;91:11-9.

  • Litou C, Vertzoni M, Goumas C, Vasdekis V, Xu W, Kesisoglou F, Reppas C. Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug - Drug Interaction Studies. Pharm Res. 2016 Jun;33(6):1399-412.

  • Reppas C, Karatza E, Goumas C, Markopoulos C, Vertzoni M. Characterization of Contents of Distal Ileum and Cecum to Which Drugs/Drug Products are Exposed During Bioavailability/Bioequivalence Studies in Healthy Adults. Pharm Res. 2015 Oct;32(10):3338-49.

  • Kourentas A, Vertzoni M, Symillides M, Hens B, Brouwers J, Augustijns P, Reppas C. In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT. Int J Pharm. 2016 Dec 30;515(1-2):352-358.

Contact

Christos Reppas
Postal address: Section of Pharmaceutical Technology,
Department of Pharmacy,
National and Kapodistrian University of Athens,
Panepistimiopolis, 157 84 Zografou,
Greece
Tel: + 30 210 727 4678
Fax: + 30 210 727 4027
e-mail: reppas[at]pharm.uoa[dot]gr