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Maria Halabalaki

Assistant Professor in the Division of Pharmacognosy and Natural Products Chemistry

Full CV

Education

  • Degree in Pharmacy, Athens (1998)
  • MSc in Natural Products Chemistry,  Department of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, National and Kapodidtrian University of Athens (2001)
  • PhD in Pharmacy, Department of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, National and Kapodidtrian University of Athens (2005)

Research topics

  • Separation and purification of natural products using chromatographic techniques (VLC, MPLC, FCPC, HPLC). Structure elucidation of natural products via spectroscopic methods (UV-Vis, IR, CID, GC-MS, LC-MS, HRMS&HRMS/MS 1&2D NMR).
  • Development of quantitative and qualitative methods for the evaluation of plant extracts using chromatographic methods, HPLC-UV & LC-MS. Structure elucidation of natural products using LC-HRMSn techniques.
  • Development and application of analytical dereplication platform (LC/UPLC-DAD-HRMS&HRMSn) for the structure-oriented isolation and identification of bioactive natural products.
  • NMR and LC/MS-based metabolomics approaches (metabolic profiling, fingerprinting) for dereplication purposes and targeted discovery of bioactive natural products.
  • Development and application of LC-MS & GC-MS-based methodologies for the analysis (qualitatively and quantitatively) of human samples (plasma, urine, faeces). Investigation of the impact of diet on gut microflora and human health.

 

Distinctions

  • 63rd International Congress and Annual Meeting of the Society of for the Medicinal Plant and Natural Products Research – GA2015, 23rd – 27th August, 2015, Budapest, Hungary. Egon Stahl in silver, a medal, a document and a monetary prize in order to recognize and promote young scientists working in the field of Pharmacognosy (Pharmaceutical Biology) and Analytical Phytochemistry. Award lecture “Integrated Metabolomic approaches in Natural Products Chemistry” http://media.wix.com/ugd/a5860a_8ea849ab51824774bc491415fd7a267b.pdf.
  • 62nd International Congress and Annual Meeting of the Society of for the Medicinal Plant and Natural Products Research – GA2014, 31st August – 4th September, 2045, Guimaraes, Portugal. Young scientists 1st award of the scientific work entitled “Quantitative study of two indirubin derivatives: 6-Bromoindirubin-3΄-oxime (6BIO) and 6-Bromoindirubin-3′-[O-(2-piperazine-1-ylethyl) oxime] (6BIO-pip) in mice plasma by LC-MS/MS. Application in a pharmacokinetic study”. J Tchoumtchoua, M Halabalaki, E Gikas, L Liu, R Joves, S Nam, LA Skaltsounis.
  • ’Irakleitos’’ 2000-2004 fellowship from National Ministry of Education for the implementation of doctoral research entitled “Phytochemical and Pharmacological study of phytoestrogens from genus Onobrychis as a source of phytoestrogens – Evaluation of the effect of O. ebenoides to osteoporosis”.

 

 

List of recent publications

  • Microchemical Journal, 2018 (in press). “Simultaneous determination of iridoids, phenylpropanoids and flavonoids in Lippia alba extracts by micellar electrokinetic capillary chromatography”. A F Gomes, M Ganzera, S Schwaiger, H Stuppner, M Halabalaki, M P Almeida, M F Leite, J G Amaral, J M David. https://doi.org/10.1016/j.microc.2018.02.003.
  • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2018 (in press).  “Roasting has a distinct effect on the antimutagenic activity of coffee varieties”. A Priftis, D Mitsioua, M Halabalaki, G Ntasi, D Stagos, L A. Skaltsounis, D Kouretas. https://doi.org/10.1016/j.mrgentox.2018.03.003.
  • Molecular Nutrition and Food Research, 2018, (in press). “Bioavailability of Terpenes and Postprandial Effect on Human Antioxidant Potential. An Open-Label Study in Healthy Subjects” E Papada, A Gioxari, V Brieudes, C Amerikanou, M Halabalaki, LA Skaltsounis, I Smyrnioudis, AC Kaliora. DOI: 10.1002/mnfr.201700751.
  • Clinica Chimica Acta, 2017 (in press).Metabolomic analysis-Addressing NMR and LC-MS related problems in human feces sample preparation” S Moosmang, M Pitscheider, S Sturm, C Seger, H Tilg, M Halabalaki, H Stuppner. https://doi.org/10.1016/j.cca.2017.10.029.
  • Antioxidants & Redox Signaling, 2017, 27(14), 1027-1047. “The indirubin derivative 6-Bromoindirubin-3'-oxime (6BIO) activates proteostatic modules, reprograms cellular bioenergetics pathways and exerts anti-aging effects” EN Tsakiri, N Gaboriaud-Kolar, KK Iliaki, J Tchoumtchoua, ED Papanagnou, S Chatzigeorgiou, KD Tallas, E Mikros, M Halabalaki, AL Skaltsounis, IP Trougakos. https://doi.org/10.1089/ars.2016.6910.

 

Contact

Ass Prof. Maria Halabalaki
National and Kapodistrian University of Athens
School of Pharmacy
Laboratory of Pharmacognosy and Natural Products Chemistry
Athens 15771, Greece
email: mariahal[at]pharm.uoa[dot]gr
Tel.: +302107274781
Fax.:+302107274594