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 Mitakou Sofia

Professor,  Department of Pharmacognosy and Natural Product Chemistry

FULL CV  

Education

  • 1987: Ph.D. (Pharmacognosy) Universite Rene Descartes-PARIS V, Paris, France  Title: " Alcaloides de Rutacees Neo-Caledoniennes: Geijera balansae, Sarcomelicope glauca et Sarcomelicope dogniensis. Etude de la reactivite du systeme ‘‘chromene’’ de pyrannoquinolones et pyrannoacridones
  • 1984: M.Sc (Pharmacognosy) Universite Rene Descartes-PARIS V, Paris, France
  • 1981: Diploma    (Pharmacy) University of Athens

Research topics

  • Search and isolation of new lead compounds with pharmaceutical, nutraceutical and cosmetic interest from natural sources (plants, marine organism, fungi, and microorganisms) from Greek, Mediterranean, as well as worldwide biodiversity.

  • Natural products structure determination using modern NMR techniques, Mass spectrometry and Molecular Modeling; metabonomics, proteomics evaluation of natural products.

  • Drug Discovery: Design and synthesis of new molecules with pharmacological interest (antitumor, antiviral, antibiotics, estrogen/antiestrogen, kinase inhibitors): structure-activity relationships.

Distinctions

  1. Unifar Prize (1984)

  2. Roussel Prize (1985)

  3. Unifar Prize (19846)

  4. Prize in Doctorate Degree, Fondation Robert (1987) 

 List of recent publications

  • J.C. FLORENT, X. DONG, G. GAUDEL, S. MITAKU, C. MONNERET, J.P. GESSON, J.C. JACQUESY, M. MONDON,B. RENOUX, S. ANDRIANOMENJANAHARY, S. MICHEL, M. KOCH, F. TILLEQUIN, M. GERKEN, J. CZECH, R. STRAUB and K. BOSSLET. Prodrugs of anthracyclines for use in Antibody Directed Enzyme Prodrug Therapy  J. Med. Chem., 1998, 41, 3572-3581.

  • M. HALABALAKI, N. ALIGIANNIS, Z. PAPOUTSI, S. MITAKU, P. MOUTSATSOU, C. SEKERIS and A.L. SKALTSOUNIS Three new arylbenzofurans from Onobruchis Ebenoides and evaluation of their Binding Affinity with Estrogen Receptor. J. Nat. Prod., 2000, 63, 1672-1674.

  • N. FOKIALAKIS, G. LABRINIDIS, D. MITSIOU, N. ALIGIANNIS, S. MITAKOU, A.L. SKALTSOUNIS, H. PRATSINIS, E. MIKROS, M. ALEXIS A new class of phytoestrogens: evaluation of the estrogenic activity of deoxybenzoins Chem. & Biology, 2004, 11, 397-406.

  • PARASCHOS, P MAGIATIS, S MITAKOU, K PETRAKI, A. KALLIAROPOULOS, P MARAGOUDAKIS, A MENTIS, D SGOURAS, AL SKALTSOUNIS. In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrobial Agents Chemother. 2007, 51, 551-9.

  • LOIZOU, S. PARASCHOS, S. MITAKOU, G. CHROUSOS, I. LEKAKIS, P. MOUTSATSOU. Chios Mastic gum extract and isolated phytosterol tirucallol exhibit anti- inflammatory activity in human aortic endothelial cells. Exp.  Biol. Med. 2009, 234, 553-61.

 

Contact

Associate Professor Mitakou Sofia
University of Athens
Faculty of Pharmacy
Department of Pharmacognosy and Natural Product Chemistry
Panepistimioupolis-Zografou
157 71 Athens
GREECE
Tel.: +30 210 7274597 Fax.: +30 210 7274594
e-mail: mitakou[at]pharm.uoa[dot]gr