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 Skaltsounis Alexios-Leandros 

Professor,  Department of Pharmacognosy and Natural Product Chemistry

FULL CV  

Research Activities

Education

  • Degree in Pharmacy: Athens (1981)
  • MSc in Medicinal Chemistry - Natural Product Chemistry: Orsay University, PARIS XI, Paris (1982)
  • MSc in Organic Chemistry: Orsay Univiversity PARIS XI, Paris (1984)
  • Ph.D. in Pharmacy (Doctorat d’Etat ès Sciences Pharmaceutiqes): Distinction with Honors, Descartes University, Paris V, Paris (1987)

Research topics

  • Isolation of new lead compounds with pharmaceutical, agrochemical, nutraceutical and cosmetic interest from natural sources (plants, marine organism, fungi, and microorganisms) originated from Mediterranean and global biodiversity 
  • Identification and structure elucidation of natural products using state-of-the-art spectroscopic techniques (NMR, HRMS) and computational studies (In silico studies & Molecular modeling) 
  • MS- and NMR-based metabolomics and proteomics 
  • Qualitative and quantitative analysis of bioactive natural products in extracts and biological fluids 
  • Design and synthesis of new molecules with pharmacological interest (antitumor,antiviral, antibiotics, estrogen/antiestrogen, kinase inhibitors); structure-activity relationships 
  • “Green” chemistry and large-scale extraction of high added value natural products.

Distinctions

  • Assistant: Pharmacognosy Laboratory, University of PARIS V, (1988-1993)
  • Assistant Professor: Department of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, University of Athens (1993-1998)Associate Professor: Department of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, University of Athens, (1998-2003)
  • Professor: Departmentof Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, University of Athens, 2003 (Director since 2004)
  • Vice Dean of the Faculty of Pharmacy, University of Athens 2005-2009
  • Dean of the Faculty of Pharmacy, University of Athens 2009

 Scientific activities & publications

  • 15 monographs. & review articles
  • Editor in 1 book and in one special issue of Planta Medica
  • 10 patents.
  • 205 publications in international journals.
  • 210 seminars/posters in international conferences.
  • Supervision of 25 PhD, since 1994
  • 75 Research grants; 12 European grants; 33 National grants; 30 Grants from private  companies
  • 6 derivatives of the natural lead compound 6-bromoindirubin, originally isolated as new natural product from Hexaplex trunculus commercialised as pharmacological tools and  biological reagents (kinase inhibitors) by Sigma-Aldrich, Merck, Calbiochem, Alexis etc.

List of recent publications

  • C. SPANOU, A.S. VESKOUKIS, T. KERASIOTI, M. KONTOU, A. ANGELIS, N. ALIGIANNIS, AL SKALTSOUNIS, D. KOURETAS Flavonoid glycosides isolated from unique legume plant extracts as novel inhibitors of xanthine oxidase. PLoS One. 2012;7,:e32214. Epub 2012 Mar 2

  • M.S. CHRISTODOULOU, N. FOKIALAKIS, S. NAM, R. JOVE, A.L. SKALTSOUNIS, S. HAROUTOUNIAN. Synthesis and In Vitro Biological Evaluation of Novel Pyrazole Derivatives as Potential Antitumor Agents. Med Chem. 2012 Jun 25 in press
  • A. Papachristoforou, A. Kagiava, C. Papaefthimiou, A. Termentzi, N. Fokialakis, AL Skaltsounis, M. Watkins, G. Arnold, G. Theophilidis The bite of the honeybee: 2-heptanone secreted from honeybee mandibles during a bite acts as a local anaesthetic in insects and mammals PLoS One. 2012, in press

  • L. LIU, M. KRITSANIDA, P. MAGIATIS, N. GABORIAUD, Y. WANG, J. WU, R. BUETTNER, F. YANG, S, NAM, AL. SKALTSOUNIS, R. JOVE A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling. Cancer biology & therapy, 2012, in press 
  • N. SATO, L. MEIJER, L. SKALTSOUNIS, P. GREENGARD, A.H.. BRIVANLOU Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signalling by a pharmacological GSK-3-specific inhibitor. Nature Medicine 2004, 10, 55-63.

 

Contact

Prof. Leandros Skaltsounis
National and Kapodistrian University of Athens
School of Pharmacy
Laboratory of Pharmacognosy and Natural Products Chemistry
Athens 15771, Greece
email: skaltsounis[at]pharm.uoa[dot]gr
Tel.: +302107274598
Fax.:+302107274594