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 Halabalaki Maria



  • Currently: Research Associate, Institute of Pharmacy/Pharmacognosy, CCB - Center for Chemistry and Biomedicine University of Innsbruck, Austria.  
  • 2012-2013: Research Fellow, in the R&D Department of BIONORICA Research phytopharmaceutical company, Innsbruck, Austria
  • 2009-today: Teaching and Research Assistant, Faculty of Pharmacy University of Athens.
  • 2006-2007: Postdoctoral researcher, Proteomics and Pharmacoproteomics Approaches, Foundation for Biomedical Research Foundation of the Academy of Athens, Center for Basic Research – Biotechnology Division-Laboratory of Proteomics (BRFAA)
  • 2005: Ph. D. in Pharmacy, Department of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy University of Athens.
  • 2001: MSc in Natural Products Chemistry, Laboratory of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, University of Athens.
  • 1998: Degree in Pharmacy, Department of Pharmacy University of Athens


Research topics

  • Separation and isolation of bioactive natural products using chromatographic techniques
  • Structure elucidation of natural products via spectroscopic methods (UV-Vis, IR, GC-MS, LC-MS, HRMS&HRMS/MS 1&2D NMR).
  • Development of quantitative and qualitative methods for the characterization of plant extracts using chromatographic methods (HPLC-UV & LC-MS).
  • Development and application of dereplication platforms (LC/UPLC-DAD-HRMS&HRMSn) for the structure-oriented isolation and identification of active natural products.
  • NMR and LC/MS-based metabolomics approaches (metabolic profiling, fingerprinting)
  • Development of proteomics and pharmacoproteomics approaches for the investigation of the biological role of natural products using nano-LC-HRMS/MS
  • Development of LC/MS-based cell metabolomics methodologies for the investigation of natural products implication in molecular pathways of cell apoptosis and discovery of cellular biomarkers. 


Memberships in International Scientific Societies

  • European Society of Pharmacognosy (PSE)
  • Society for Medicinal Plant and Natural Product Research (GA)
  • American Society of Pharmacognosy (ASP)
  • Metabolomics Society
  • International Society for Horticultural Science (ISHS)


List of recent publications

  • Journal of Mass Spectrometry, 2014. "Ion tree-based structure elucidation of acetophenones dimers from Acronychia pedunculata (AtA) and their identification in extracts by liquid chromatography electrospray ionization LTQ-Orbitrap mass spectrometry” E Kouloura, LA. Skaltsounis, S Michel, M Halabalaki, in press.
  • Phytochemical Analysis, 2013, 25(4):350-6. “Sample preparation issues in NMR-based plant metabolomics: optimisation for Vitis wood samples”.M Halabalaki, S Bertrand, A Stefanou, K Gindro, S Kostidis, E Mikros, LA Skaltsounis, JL Wolfender. doi: 10.1002/pca.2497
  • European Journal of Nutrition, 2013, 3(4):1073-81. “Impact of a functionalized olive oil extract on the uterus and the bone in a model of postmenopausal osteoporosis”. A Keiler, O Zierau, R Bernhardt, N Lemonakis, A Termentzi, L Skaltsounis, G Vollmer, M Halabalaki. doi: 10.1007/s00394-013-0609-4.
  • Journal of Proteomic Research, 2013, 12(4), 1591-1603. “Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level”. TI Roumeliotis#, M Halabalaki#, X Alexi, D Ankrett, E Giannopoulou, A-L Skaltsounis, B S. Sayan, MN. Alexis, PA. Townsend, SD Garbis. www.ncbi.nlm.nih.gov/pubmed/24077107
  • Journal of Mass Spectrometry, 2013, 48(5), 561-75: "Structure-oriented UHPLC-LTQ Orbitrap-based approach as a dereplication strategy for the identification of isoflavonoids from Amphimas pterocarpoides crude extract". J Tchoumtchoua, D Njamen, JC Mbanya, AL Skaltsounis, M Halabalaki. doi: 10.1002/jms.3167.
  • Journal of Natural Products, 2012, 75(7), 1270-1276 “Cytotoxic Prenylated Acetophenone Dimers from Acronychia pedunculata” E Kouloura, M Halabalaki, MC Lallemand, S Nam, R Jove, M Litaudon, H Awang, H A. Hadi, and AL Skaltsounis. doi: 10.1021/np201007a
  • Journal of Separation Science, 2011, 34, 1-10: “One-step isolation of γ-oryzanol from rice bran oil by non-aqueous hydrostatic countercurrent chromatography”. A Angelis, A Urbain, M Halabalaki, N Aligiannis, AL Skaltsounis. doi: 10.1002/jssc.201100192.
  • Current Opinion in Biotechnology, 2014, 25, 1-7. “Recent advances and new strategies in the NMR-based identification of natural products”. M Halabalaki, K Vougogiannopoulou, E Mikros and AL Skaltsounis. doi: 10.1016/j.copbio.2013.08.005
  • Encyclopedia of Analytical Chemistry, Handbook of Chemical and Biological Plant Analytical Methods, 2014, 1–53. Plant Sesquiterpenes and other Terpenoids. “Sesquiterpenoids and other terpenoids”. E Kouloura, J Tchoumtchoua, M Halabalaki, AL Skaltsounis. (Editors), K Hostettmann, A Marston, H Stuppner, S Chen, John Wiley & Sons, Ttd, UK.DOI: 10.1002/9780470027318.a9928



  • National and Kapodistrian University of Athens –NKUA,Faculty of Pharmacy, Department of Pharmacognosy and Chemistry of Natural Products, Athens 15771, Greece, Tel & Fax: + 30210 727-459.
    E-mail: mariahal[at]pharm.uoa[dot]gr
  • University of Innsbruck, Institute of Pharmacy/Pharmacognosy, CCB-Center for Chemistry and Biomedicine, Innrain 80-82, 6020 Innsbruck, AUSTRIA. Tel.: +43-512-507-58413.
    E-mail: maria.halabalaki[at]uibk.ac[dot]at