Homepage » Year Book 2016

Publications

  • Abedini, A., Chollet, S., Angelis, A., Borie, N., Nuzillard, J.-M., Skaltsounis, A.-L., Reynaud, R., Gangloff, S.C., Renault, J.-H., and Hubert, J. (2016). Bioactivity-guided identification of antimicrobial metabolites in Alnus glutinosa bark and optimization of oregonin purification by Centrifugal Partition Chromatography. Journal of Chromatography B 1029–1030, 121–127.
  • Agrawal, K., Holt, R.R., Li, X., Melliou, E., Pedersen, T.L., Wang, S.C., Flynn, D., Magiatis, P., and Newman, J.W. (2016). Effects of extra virgin olive oil oleocanthal and oleacein content on platelet reactivity in healthy adults.
  • Alexandropoulos, I.I., Argyriou, A.I., Marousis, K.D., Topouzis, S., Papapetropoulos, A., and Spyroulias, G.A. (2016). 1H, 13C, 15N backbone and side-chain resonance assignment of Nostoc sp. C139A variant of the heme–nitric oxide/oxygen binding (H-NOX) domain. Biomolecular NMR Assignments 10, 395–400.
  • Alguel, Y., Amillis, S., Leung, J., Lambrinidis, G., Capaldi, S., Scull, N.J., Craven, G., Iwata, S., Armstrong, A., Mikros, E., et al. (2016). Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity. Nature Communications 7, 11336.
  • Aligiannis, N., Halabalaki, M., Chaita, E., Kouloura, E., Argyropoulou, A., Benaki, D., Kalpoutzakis, E., Angelis, A., Stathopoulou, K., Antoniou, S., et al. (2016). Heterocovariance Based Metabolomics as a Powerful Tool Accelerating Bioactive Natural Product Identification. ChemistrySelect 1, 2531–2535.
  • Anastasia, P., Tchoumtchoua, J., Passali, C., Pavlos, L., and Kourkoulis, S. (2016). The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats. Medicinal & Aromatic Plants 5.
  • Andreadou, I., Mitakou, S., Paraschos, S., Efentakis, P., Magiatis, P., Kaklamanis, L., Halabalaki, M., Skaltsounis, L., and Iliodromitis, E.K. (2016). “Pistacia lentiscus L.” reduces the infarct size in normal fed anesthetized rabbits and possess antiatheromatic and hypolipidemic activity in cholesterol fed rabbits. Phytomedicine 23, 1220–1226.
  • Angelis, A., Hubert, J., Aligiannis, N., Michalea, R., Abedini, A., Nuzillard, J.-M., Gangloff, S., Skaltsounis, A.-L., and Renault, J.-H. (2016). Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules 21, 1586.
  • Arsenijević, J., Drobac, M., Šoštarić, I., Ražić, S., Milenković, M., Couladis, M., and Maksimović, Z. (2016). Bioactivity of herbal tea of Hungarian thyme based on the composition of volatiles and polyphenolics. Industrial Crops and Products 89, 14–20.
  • Atwi, M., Weiss, E.-K., Loupassaki, S., Makris, D.P., Ioannou, E., Roussis, V., and Kefalas, P. (2016). Major Antioxidant Polyphenolic Phytochemicals of Three Salvia Species Endemic to the Island of Crete. Journal of Herbs, Spices & Medicinal Plants 22, 27–34.
  • Ben, Y., Fakhfakh, J., Tchoumtchoua, J., Halabalaki, M., and Allouche, N. (2016). Efficient purification and complete NMR characterization of galactinol, sucrose, raffinose, and stachyose isolated from Pinus halepensis (Aleppo pine) seeds using acetylation procedure. Journal of Carbohydrate Chemistry 35, 224–237.
  • Ben Mansour, A., Gargouri, B., Melliou, E., Magiatis, P., and Bouaziz, M. (2016). Oil quality parameters and quantitative measurement of major secoiridoid derivatives in Neb Jmel olive oil from various Tunisian origins using qNMR. Journal of the Science of Food and Agriculture 96, 4432–4439.
  • Bibli, S.-I., Andreadou, I., Glynos, C., Chatzianastasiou, A., Toumpanakis, D., Zakynthinos, S., Vasilakopoulos, T., Iliodromitis, E.K., and Papapetropoulos, A. (2016). Exposure to cigarette smoke abrogates the beneficial effect of ischemic postconditioning. American Journal of Physiology - Heart and Circulatory Physiology 311, H1321–H1332.
  • Brancaleone, V., Esposito, I., Gargiulo, A., Vellecco, V., Asimakopoulou, A., Citi, V., Calderone, V., Gobbetti, T., Perretti, M., Papapetropoulos, A., et al. (2016). -Penicillamine modulates hydrogen sulfide (H 2 S) pathway through selective inhibition of cystathionine-γ-lyase: d -penicillamine selectively inhibits CSE. British Journal of Pharmacology 173, 1556–1565.
  • Brancaleone, V., Esposito, I., Gargiulo, A., Vellecco, V., Asimakopoulou, A., Citi, V., Calderone, V., Gobbetti, T., Perretti, M., Papapetropoulos, A., et al. (2016). d-Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyase. British Journal of Pharmacology 173, 1556–1565.
  • Brieudes, V., Angelis, A., Vougogiannopoulou, K., Pratsinis, H., Kletsas, D., Mitakou, S., Halabalaki, M., and Skaltsounis, L.A. (2016). Phytochemical Analysis and Antioxidant Potential of the Phytonutrient-Rich Decoction of Cichorium spinosum and Cintybus. Planta Medica 82, 1070–1078.
  • Brieudes, V., Angelis, A., Vougogiannopoulou, K., Pratsinis, H., Kletsas, D., Mitakou, S., Halabalaki, M., and Skaltsounis, L. (2016). Phytochemical Analysis and Antioxidant Potential of the Phytonutrient-Rich Decoction of Cichorium spinosum and C. intybus. Planta Medica 82, 1070–1078.
  • Calapai, G., Minciullo, P.L., Miroddi, M., Chinou, I., Gangemi, S., and Schmidt, R.J. (2016). Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - Part 3: Mentha × piperita - Solanum dulcamara. Contact Dermatitis 74, 131–144.
  • Cao, S.-E., Chen, S.-Y., Tian, J.-M., Zhang, X.-R., Liu, J., Gong, H.-Y., and Yue, X.-Q. (2016). Intrathecal Delivery of Ketorolac Loaded <i>In Situ</i> Gels for Prolonged Analgesic and Anti-Inflammatory Activity in Vertebral Fracture. Tropical Journal of Pharmaceutical Research 15, 5.
  • Chao, C., and Zatarain, J.R. (2016). Cystathionine-β-Synthase Inhibition for Colon Cancer: Enhancement of the Efficacy of Aminooxyacetic Acid via the Prodrug Approach. Molecular Medicine 22, 1.
  • Chatzianastasiou, A., Bibli, S.-I., Andreadou, I., Efentakis, P., Kaludercic, N., Wood, M.E., Whiteman, M., Di Lisa, F., Daiber, A., Manolopoulos, V.G., et al. (2016). Cardioprotection by H2S Donors: Nitric Oxide-Dependent and -Independent Mechanisms. Journal of Pharmacology and Experimental Therapeutics 358, 431–440.
  • Cottet, K., Kouloura, E., Kritsanida, M., Wansi, J.-D., Odonne, G., Michel, S., Halabalaki, M., and Lallemand, M.-C. (2016). Comparative metabolomic study between African and Amazonian Symphonia globulifera by tandem LC-HRMS.
  • Damianakos, H., Jeziorek, M., Sykłowska-Baranek, K., Buchwald, W., Pietrosiuk, A., and Chinou, I. (2016). Pyrrolizidine alkaloids from Cynoglossum columnae Ten. (Boraginaceae). Phytochemistry Letters 15, 234–237.
  • Demetzos, K., Tsantili, A., Sklatsa, E., Siamidi, A., Koutepas, G., Pippa, N., Gardikis, K., Chinou, I., Tzakou, O., Hantziantoniou, S., et al. (2016). Stimuli-responsive survey of HPS to detect learning attitudes and needs of Greek pharmacists towards CPD. European Journal of Pharmaceutical Sciences 93, I–IV.
  • Dimopoulou, M., Mourouti, C.-S., Vertzoni, M., Symillides, M., and Reppas, C. (2016). In-vitro evaluation of performance of solid immediate release dosage forms of weak bases in upper gastrointestinal lumen: experience with miconazole and clopidogrel salts: Biorelevant evaluation of weak bases. Journal of Pharmacy and Pharmacology 68, 579–587.
  • Dimou, M., Ioannou, E., Daskalaki, M.G., Tziveleka, L.A., Kampranis, S.C., and Roussis, V. (2016). Disulfides with Anti-inflammatory Activity from the Brown Alga Dictyopteris membranacea. Journal of Natural Products 79, 584–589.
  • Druzhyna, N., Szczesny, B., Olah, G., Módis, K., Asimakopoulou, A., Pavlidou, A., Szoleczky, P., Gerö, D., Yanagi, K., Törö, G., et al. (2016). Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer. Pharmacological Research 113, 18–37.
  • Durieu, E., Prina, E., Leclercq, O., Oumata, N., Gaboriaud-Kolar, N., Vougogiannopoulou, K., Aulner, N., Defontaine, A., No, J.H., Ruchaud, S., et al. (2016). From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity. Antimicrobial Agents and Chemotherapy 60, 2822–2833.
  • Efentakis, P., Andreadou, I., Bibli, S.-I., Vasileiou, S., Dagres, N., Zoga, A., Lougiakis, N., Kremastinos, D.T., and Iliodromitis, E.K. (2016). Ranolazine triggers pharmacological preconditioning and postconditioning in anesthetized rabbits through activation of RISK pathway. European Journal of Pharmacology 789, 431–438.
  • Faqueti, L.G., Brieudes, V., Halabalaki, M., Skaltsounis, A.L., Nascimento, L.F., Barros, W.M., Santos, A.R.S., and Biavatti, M.W. (2016). Antinociceptive and anti-inflammatory activities of standardized extract of polymethoxyflavones from Ageratum conyzoides. Journal of Ethnopharmacology 194, 369–377.
  • Foivas, A., Malenović, A., Kostić, N., Božić, M., Knežević, M., Loukas, Y.L., and Dotsikas, Y. (2016). Quantitation of brinzolamide in dried blood spots by a novel LC-QTOF-MS/MS method. Journal of Pharmaceutical and Biomedical Analysis 119, 84–90.
  • Foscolos, A.-S., Papanastasiou, I., Foscolos, G.B., Tsotinis, A., Kellici, T.F., Mavromoustakos, T., Taylor, M.C., and Kelly, J.M. (2016). New hydrazones of 5-nitro-2-furaldehyde with adamantanealkanohydrazides: synthesis and in vitro trypanocidal activity. Med. Chem. Commun. 7, 1229–1236.
  • Fouseki, M.M., Damianakos, H., Karikas, G.A., Roussakis, C., P.Gupta, M., and Chinou, I. (2016). Chemical constituents from Cordia alliodora and C. colloccoca (Boraginaceae) and their biological activities. Fitoterapia 115, 9–14.
  • Gaboriaud-Kolar, N., Myrianthopoulos, V., Vougogiannopoulou, K., Gerolymatos, P., Horne, D.A., Jove, R., Mikros, E., Nam, S., and Skaltsounis, A.-L. (2016). Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines. Journal of Natural Products 79, 2464–2471.
  • Gangwal, R.P., Damre, M.V., and Sangamwar, A.T. (2016). Overview and Recent Advances in QSAR Studies. In Chemometrics Applications and Research: QSAR in Medicinal Chemistry, (Apple Academic Press), pp. 1–32.
  • Georgantea, P., Ioannou, E., Evain-Bana, E., Bagrel, D., Martinet, N., Vagias, C., and Roussis, V. (2016). Sesquiterpenes with inhibitory activity against CDC25 phosphatases from the soft coral Pseudopterogorgia rigida. Tetrahedron 72, 3262–3269.
  • Giannouli, V., Lougiakis, N., Kostakis, I.K., Pouli, N., Marakos, P., Skaltsounis, A.-L., Nam, S., Jove, R., Horne, D., Tenta, R., et al. (2016). The discovery of new cytotoxic pyrazolopyridine derivatives. Bioorganic & Medicinal Chemistry Letters 26, 5229–5233.
  • Graikou, K., Popova, M., Gortzi, O., Bankova, V., and Chinou, I. (2016). Characterization and biological evaluation of selected Mediterranean propolis samples. Is it a new type? LWT - Food Science and Technology 65, 261–267.
  • Holt, R., Agarwal, K., Li, X., Melliou, E., Pedersen, T., Wang, S., Flynn, D., Magiatis, P., and Newman, J. (2016). Effects of Extra Virgin Olive Oil (EVOO) Oleocanthal and Oleacein Content on Platelet Reactivity in Healthy Adults. In Meeting Abstract, pp. 2–6.
  • Homeyer, N., Ioannidis, H., Kolarov, F., Gauglitz, G., Zikos, C., Kolocouris, A., and Gohlke, H. (2016). Interpreting Thermodynamic Profiles of Aminoadamantane Compounds Inhibiting the M2 Proton Channel of Influenza A by Free Energy Calculations. Journal of Chemical Information and Modeling 56, 110–126.
  • Hornyak, P., Askwith, T., Walker, S., Komulainen, E., Paradowski, M., Pennicott, L.E., Bartlett, E.J., Brissett, N.C., Raoof, A., Watson, M., et al. (2016). Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal 473, 1869–1879.
  • Hubert, J., Angelis, A., Aligiannis, N., Rosalia, M., Abedini, A., Bakiri, A., Reynaud, R., Nuzillard, J.-M., Gangloff, S., Skaltsounis, A.-L., et al. (2016). In Vitro Dermo-Cosmetic Evaluation of Bark Extracts from Common Temperate Trees. Planta Medica 82, 1351–1358.
  • Ignea, C., Athanasakoglou, A., Ioannou, E., Georgantea, P., Trikka, F.A., Loupassaki, S., Roussis, V., Makris, A.M., and Kampranis, S.C. (2016). Carnosic acid biosynthesis elucidated by a synthetic biology platform. Proceedings of the National Academy of Sciences 113, 3681–3686.
  • Ignea, C., Ioannou, E., Georgantea, P., Trikka, F.A., Athanasakoglou, A., Loupassaki, S., Roussis, V., Makris, A.M., and Kampranis, S.C. (2016). Production of the forskolin precursor 11β-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities. Microbial Cell Factories 15.
  • Ioannidis, H., Drakopoulos, A., Tzitzoglaki, C., Homeyer, N., Kolarov, F., Gkeka, P., Freudenberger, K., Liolios, C., Gauglitz, G., Cournia, Z., et al. (2016). Alchemical Free Energy Calculations and Isothermal Titration Calorimetry Measurements of Aminoadamantanes Bound to the Closed State of Influenza A/M2TM. Journal of Chemical Information and Modeling 56, 862–876.
  • Jones, D.S., Dressman, J.B., Dimopoulou, M., Mourouti, C.-S., Vertzoni, M., Symillides, M., and Reppas, C. (2016). In-vitro evaluation of performance of solid immediate release dosage forms of weak bases in upper gastrointestinal lumen: Experience with miconazole and clopidogrel salts. Journal of Pharmacy and Pharmacology 68, 579–587.
  • Karalis, V. (2015). From Bioequivalence to Biosimilarity: The Rise of a Novel Regulatory Framework. Drug Research 66, 1–6.
  • Karalis, V. (2016). Modeling and Simulation in Bioequivalence. In Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics, (Cham: Springer International Publishing), pp. 227–254.
  • Karatza, E., Vertzoni, M., Muenster, U., and Reppas, C. (2016). The Impact of Handling and Storage of Human Fecal Material on Bacterial Activity. Journal of Pharmaceutical Sciences 105, 3458–3461.
  • Karygianni, L., Al-Ahmad, A., Argyropoulou, A., Hellwig, E., Anderson, A.C., and Skaltsounis, A.L. (2016). Natural Antimicrobials and Oral Microorganisms: A Systematic Review on Herbal Interventions for the Eradication of Multispecies Oral Biofilms. Frontiers in Microbiology 6.
  • Katsarou, M., Latsi, R., Papasavva, M., Demertzis, N., Kalogridis, T., Tsatsakis, A., Spandidos, D., and Drakoulis, N. (2016). Population-based analysis of the frequency of HFE gene polymorphisms: Correlation with the susceptibility to develop hereditary hemochromatosis. Molecular Medicine Reports.
  • Katsouda, A., Bibli, S.-I., Pyriochou, A., Szabo, C., and Papapetropoulos, A. (2016). Regulation and role of endogenously produced hydrogen sulfide in angiogenesis. Pharmacological Research 113, 175–185.
  • Kellici, T.F., Chatziathanasiadou, M.V., Diamantis, D., Chatzikonstantinou, A.V., Andreadelis, I., Christodoulou, E., Valsami, G., Mavromoustakos, T., and Tzakos, A.G. (2016). Mapping the interactions and bioactivity of quercetin⿿(2-hydroxypropyl)-β-cyclodextrin complex. International Journal of Pharmaceutics 511, 303–311.
  • Kellici, T.F., Ntountaniotis, D., Kritsi, E., Zervou, M., Zoumpoulakis, P., Potamitis, C., Durdagi, S., Salmas, R.E., Ergun, G., Gokdemir, E., et al. (2016). Leveraging NMR and X-ray data of the free ligands to build better drugs targeting angiotensin II Type 1 G-Protein coupled receptor. Current Medicinal Chemistry 23, 36–59.
  • Kiriazopoulos, E., Zaharaki, S., Vonaparti, A., Vourna, P., Panteri-Petratou, E., Gennimata, D., Lombardo, K., and Panderi, I. (2016). Quantification of three beta-lactam antibiotics in breast milk and human plasma by hydrophilic interaction liquid chromatography/positive-ion electrospray ionization mass spectrometry: Quantification of beta-lactam antibiotics in breast milk and human plasma by HILIC-ESI/MS. Drug Testing and Analysis.
  • Koperniku, A., Foscolos, A.-S., Papanastasiou, I., B. Foscolos, G., Tsotinis, A., and Schols, D. (2016). 4-(1-Adamantyl)phenylalkylamines with Potential Antiproliferative Activity. Letters in Organic Chemistry 13, 171–176.
  • Kourentas, A., Vertzoni, M., Khadra, I., Symillides, M., Clark, H., Halbert, G., Butler, J., and Reppas, C. (2016). Evaluation of the Impact of Excipients and an Albendazole Salt on Albendazole Concentrations in Upper Small Intestine Using an In Vitro Biorelevant Gastrointestinal Transfer (BioGIT) System. Journal of Pharmaceutical Sciences 105, 2896–2903.
  • Kourentas, A., Vertzoni, M., Stavrinoudakis, N., Symillidis, A., Brouwers, J., Augustijns, P., Reppas, C., and Symillides, M. (2016). An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation. European Journal of Pharmaceutical Sciences 82, 106–114.
  • Kourentas, A., Vertzoni, M., Symillides, M., Goumas, K., Gibbon, R., Butler, J., and Reppas, C. (2016). Effectiveness of supersaturation promoting excipients on albendazole concentrations in upper gastrointestinal lumen of fasted healthy adults. European Journal of Pharmaceutical Sciences 91, 11–19.
  • Kourentas, A., Vertzoni, M., Symillides, M., Hens, B., Brouwers, J., Augustijns, P., and Reppas, C. (2016). In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT. International Journal of Pharmaceutics 515, 352–358.
  • Kourentas, A., Vertzoni, M., Khadra, I., Symillides, M., Clark, H., Halbert, G., Butler, J., and Reppas, C. (2016). Evaluation of the Impact of Excipients and an Albendazole Salt on Albendazole Concentrations in Upper Small Intestine Using an In Vitro Biorelevant Gastrointestinal Transfer (BioGIT) System. Journal of Pharmaceutical Sciences 105, 2896–2903.
  • Kourentas, A., Vertzoni, M., Stavrinoudakis, N., Symillidis, A., Brouwers, J., Augustijns, P., Reppas, C., and Symillides, M. (2016). An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation. European Journal of Pharmaceutical Sciences 82, 106–114.
  • Kourentas, A., Vertzoni, M., Symillides, M., Goumas, K., Gibbon, R., Butler, J., and Reppas, C. (2016i). Effectiveness of supersaturation promoting excipients on albendazole concentrations in upper gastrointestinal lumen of fasted healthy adults. European Journal of Pharmaceutical Sciences 91, 11–19.
  • Kourentas, A., Vertzoni, M., Symillides, M., Hens, B., Brouwers, J., Augustijns, P., and Reppas, C. (2016k). In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT. International Journal of Pharmaceutics 515, 352–358.
  • Koutsaviti, A., Tzini, D.I., and Tzakou, O. (2016). Greek Salvia sclarea L. Essential Oils: Effect of Hydrodistillation Time, Comparison of the Aroma Chemicals Using Hydrodistillation and HS-SPME Techniques. Records of Natural Products 10, 800.
  • Kukula-Koch, W., Koch, W., Angelis, A., Halabalaki, M., and Aligiannis, N. (2016). Application of pH-zone refining hydrostatic countercurrent chromatography (hCCC) for the recovery of antioxidant phenolics and the isolation of alkaloids from Siberian barberry herb. Food Chemistry 203, 394–401.
  • Kyriazis, I.D., Koutsoni, O.S., Aligiannis, N., Karampetsou, K., Skaltsounis, A.-L., and Dotsika, E. (2016). The leishmanicidal activity of oleuropein is selectively regulated through inflammation- and oxidative stress-related genes. Parasites & Vectors 9, 441.
  • Lambrinoudaki, I., Augoulea, A., Rizos, D., Politi, M., Tsoltos, N., Moros, M., Chinou, I., Graikou, K., Kouskouni, E., Kambani, S., et al. (2016). Greek-origin royal jelly improves the lipid profile of postmenopausal women. Gynecol. Endocrinol. 32, 835–839.
  • Lemonakis, N., Mougios, V., Halabalaki, M., Skaltsounis, A.L., and Gikas, E. (2016). A novel bioanalytical method based on UHPLC-HRMS/MS for the quantification of oleuropein in human serum. Application to a pharmacokinetic study. Biomedical Chromatography 30, 2016–2023.
  • Lemonakis, N., Mougios, V., Halabalaki, M., Skaltsounis, A.-L., and Gikas, E. (2016). A novel bioanalytical method based on UHPLC-HRMS/MS for the quantification of oleuropein in human serum. Application to a pharmacokinetic study: Quantification of oleuropein in human serum. Biomedical Chromatography 30, 2016–2023.
  • Lemonakis, N., Mougios, V., Halabalaki, M., Skaltsounis, A.-L., and Gikas, E. (2016). A novel bioanalytical method based on UHPLC-HRMS/MS for the quantification of oleuropein in human serum. Application to a pharmacokinetic study: Quantification of oleuropein in human serum. Biomedical Chromatography 30, 2016–2023.
  • Lemonakis, N., Skaltsounis, A.-L., Tsarbopoulos, A., and Gikas, E. (2016). Optimization of parameters affecting signal intensity in an LTQ-orbitrap in negative ion mode: A design of experiments approach. Talanta 147, 402–409.
  • Litou, C., Vertzoni, M., Goumas, C., Vasdekis, V., Xu, W., Kesisoglou, F., and Reppas, C. (2016). Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug – Drug Interaction Studies. Pharmaceutical Research 33, 1399–1412.
  • Lougiakis, N., Gavriil, E.-S., Kairis, M., Sioupouli, G., Lambrinidis, G., Benaki, D., Krypotou, E., Mikros, E., Marakos, P., Pouli, N., et al. (2016). Design and synthesis of purine analogues as highly specific ligands for FcyB, a ubiquitous fungal nucleobase transporter. Bioorganic & Medicinal Chemistry 24, 5941–5952.
  • Lougiakis, N., Papapetropoulos, A., Gikas, E., Toumpas, S., Efentakis, P., Wedmann, R., Zoga, A., Zhou, Z., Iliodromitis, E.K., Skaltsounis, A.-L., et al. (2016). Synthesis and Pharmacological Evaluation of Novel Adenine–Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents. Journal of Medicinal Chemistry 59, 1776–1790.
  • Mamoucha, S., Fokialakis, N., and Christodoulakis, N.S. (2016). Leaf structure and histochemistry of Ficus carica (Moraceae), the fig tree. Flora - Morphology, Distribution, Functional Ecology of Plants 218, 24–34.
  • Manoukian, P., Melliou, E., Liouni, M., and Magiatis, P. (2016). Identification and quantitation of benzoxazinoids in wheat malt beer by qNMR and GC–MS. LWT-Food Science and Technology 65, 1133–1137.
  • Markantonis, S.L., Melemeni, A., Markidou, M., Haikali, S.I., Karalis, V., and Fassoulaki, A. (2016). Ropivacaine, Interleukin-6 and Tumor Necrosis Factor Alpha Plasma Levels during Intermittent Epidural and Continuous Wound Infusion of Ropivacaine for Analgesia after Hysterectomy or Myomectomy: An Observational Study. Pharmacology 98, 294–298.
  • Marniemi, J., and Parkki, M.G. (1975). Radiochemical assay of glutathione S-epoxide transferase and its enhancement by phenobarbital in rat liver in vivo. Biochem. Pharmacol. 24, 1569–1572.
  • Matralis, A., Bavavea, E.-I., Incerpi, S., Pedersen, J., and Kourounakis, A. (2016). Balancing Antioxidant, Hypolipidemic and Anti-inflammatory Activity in a Single Agent: The Example of 2-Hydroxy-2-Substituted Morpholine, 1,4-Benzoxazine and 1,4-Benzothiazine Derivatives as a Potential Therapeutic Approach against Atherosclerosis. Current Medicinal Chemistry 23, 1–1.
  • Michailidou, M., Giannouli, V., Kotsikoris, V., Papadodima, O., Kontogianni, G., Kostakis, I.K., Lougiakis, N., Chatziioannou, A., Kolisis, F.N., Marakos, P., et al. (2016). Novel pyrazolopyridine derivatives as potential angiogenesis inhibitors: Synthesis, biological evaluation and transcriptome-based mechanistic analysis. European Journal of Medicinal Chemistry 121, 143–157.
  • Myrianthopoulos, V., Gaboriaud-Kolar, N., Tallant, C., Hall, M.-L., Grigoriou, S., Brownlee, P.M., Fedorov, O., Rogers, C., Heidenreich, D., Wanior, M., et al. (2016). Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis. Journal of Medicinal Chemistry 59, 8787–8803.
  • Negrei, C., Hudita, A., Ginghina, O., Galateanu, B., Voicu, S.N., Stan, M., Costache, M., Fenga, C., Drakoulis, N., and Tsatsakis, A.M. (2016). Colon Cancer Cells Gene Expression Signature As Response to 5- Fluorouracil, Oxaliplatin, and Folinic Acid Treatment. Frontiers in Pharmacology 7.
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