ORGANIC CHEMISTRY II

(Compulsory / Teaching hours per week: 4 / Laboratory hours per week: - /Assessment: final exam at the end of each term or September/ Credits: 5 )

Teacher:

Antonios Kolocouris (Associate Professor) 

Course site (e-class): eclass.uoa.gr/courses/PHARM110/

Topics:

-Aliphatic Amines 
-Carboxylic acids and derivatives 
-Nucleophilic acyl substitution of carboxylic acid derivatives (acyl halides, anhydrides, esters, amides, nitriles etc): mechanism and reactions 
-Enolate chemistry: alpha-substitution reactions, malonic ester and acetoacetic ester synthesis, Claisen and Dieckmann condensation, Michael addition etc
-Benzene and the aromatic ring-aromaticity
-Electrophilic aromatic substitution - Benzene derivatives chemistry
a) Halogenation, nitration, sulfonation, Friedel-Crafts reactions
b) Orientation in electrophilic aromatic substitution, effects of multiple substituents
c) Side-chain reactions (halogenation, oxidation), reduction
d) Synthetic utility of electrophilic aromatic substitution
e) Aromatic amines (basicity, diazonium salts, reactions, application to synthesis)
f) Examples of the synthetis of aromatic compounds
-Spectroscopy of organic compounds (NMR, IR)
-Sugars, structure and conformation of simple sugars, reactions
-Structure of nucleic acids

    • Proposed textbooks

J. McMurry, Organic Chemistry (textbook, translated in Greek)

D. Klein, Organic Chemistry (textbook, translated in Greek)

Organic Chemistry, by R. T. Morrison and R. N. Boyd (translated in Greek); this textbook is particularly valuable for self-teaching.
Introduction to organic chemistry, by A. Streitwieser, C. H. Heathcock and E. M. Kosower.

Organic Chemistry, by Jonathan Clayden, Nick Greeves, Stuart Warren, Peter Wothers.

3000 Solved Problems in Organic Chemistry, (Schaum's Solved Problems), by H. Meislich , E. Meislich, J. Sharefkin (a version of this book translated in Greek is commercially available); recommended for students preparation for the exams.

    • Chemistry Teaching Resources

www.cem.msu.edu/~reusch/VirtualText/intro1.htm (virtual textbooks of organic chemistry)

www.organic-chemistry.org/ (an excellent site with material for advanced students)

www.organic-chemistry.org/namedreactions/ (named reactions in organic chemistry: an excellent site with material for advanced students)

blog.chembark.com/2006/04/16/the-top-10-organic-chemists-of-all-time/ (a site including archive of famous organic chemists)

www.monomerchem.com/display4.html (named reactions in organic chemistry: an excellent site with material for advanced students-some reactions are animated)

www.chemhelper.com/index.html (a site which among others includes mechanisms of many organic reactions)

www.chemistry.ohio-state.edu/organic/flashcards/ (an educational resource for reviewing organic reactions)

en.wikipedia.org/wiki/Organic_reaction (a free encyclopedia for organic chemistry)

www.chem.uci.edu/events/7062 (an excellent web-page with research level synthetic problems)

www.organicdivision.org/links.html (useful organic chemistry links)