BIOPHARMACEUTICS – PHARMACOKINETICS II

(Elective / Teaching hours per week: 3 / Assessment: final exam at the end of each term or September/ Credits: 3)

Teachers: 

C. Reppas (Professor), G. Valsami (Associate Professor), M. Symillidou (Associate Professor), M. Vertzoni (Assistant Professor)

Course site (e-class):  https://eclass.uoa.gr/courses/PHARM172/  

Topics:

    • Introduction
    • Single dose administration - Two compartment open model: iv bolus injection
    • Repeated dose administration-Non-compartmental analysis: Superposition
    • Repeated dose administration - One compartment open model: iv bolus and per os administration
    • Drug absorption after per os administration to children: population, products, GI physiology in children, food effect on absorption, clinical studies
    • Drug absorption after per os administration to the elderly: GI physiology in the elderly and effect on drug absorption
    • Non-oral extravascular administration of drugs: Oral inhalation, nasal, oral cavity, transdermal, intramuscular, rectal, vaginal, ocular
    • Distribution of drugs into the Central Nervous System
    • Pharmacokinetic – Pharmacodynamic modelling: Basic concepts
    • Biopharmaceuticals: Basic concepts and Pharmacokinetic / Pharmacodynamic issues