DRUG DESIGN

(Elective / Winter Semester / Teaching hours per week: 3 / Laboratory hours: 10 /Assessment: final exam at the end of each term or September– lab work paper/ Credits:  )

Teachers: 

Mikros Emmanuel Professor 
KourounakiAngelikiAssociate Professor 
GikasEvangelosAssistant Professor 
Lambrinidis George Lab Teaching Personnel 

Course site (e-class): https://eclass.uoa.gr/courses/PHARM122/

Topics:

    • Drug Targets: Protein structure, protein-ligand interactions.Enzymes and Receptors (GPCR, ion channels, nuclear receptors)
    • Lead Discovery. Disease biochemistry and drug design. Approach through the molecular mechanism of drug action.
    • Lead optimization. Effect of functional groups and stereochemistry / enantiomers on drug-receptor interactions (and more generally on the biological activity of compounds). Equivalent compounds, groups. Bio-ester.