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REKKAS DIMITRIOS

Associate Professor of Pharmaceutical Technology

Brief presentation of technologies and research activities

Quality By Design

 

 

Education

  • B.Pharm.University of Athens,Greece,
  • PhD in Pharmaceutical Technology,University of Athens,Greece.
  • MSc in Total Quality Management,Sheffield Hallam University,UK.      

 

Research-Teaching -Writing interests

 

  • Pharmaceutical Technology
  • Industrial Pharmacy
  • Dosage Form Design
  • Experimental Design
  • Statistical Process Control
  • Quality Control
  • Quality Assurance
  • Total Quality Management
  • Quality by Design (QbD)

 

Other Activities

  • Invited speaker on current Good Manufacturing Practices for Pharmaceutical Products, Industrial Pharmacy, Experimental Design, Total Quality Management, Quality Control and Assurance, Dosage Form Design, Quality by Design.
  • Erasmus Socrates Coordinator.
  • Visiting Scientist at the Food and Drug Administration (FDA).
  • Vice President of the Management Committee of the European Program COST 865- Bioencapsulation.
  • Invited Professor at the School of Pharmacy, University of Vienna, Austria, University of Parma and University of Ferrara, Italy
  • Scientific coordinator of an e-learning program on Total Quality Management, UoA.
  • Member of the international affairs committee of the University of Athens.
  • Director of Pharmaceutical Technology Laboratory.
  • Director of the Pharmaceutical Technology division
  • Member of the SimInhale Cost Action MP1404 on inhaled medicines.
  • Dean of the Department of Pharmacy,NKUA.

 

Publications

Papers

  • Politis S.N., Rekkas D.M., Pelletization Processes for Pharmaceutical Applications: A Patent Review. Recent Patents on Drug Delivery and Formulation 5,1,61-78,2010.

  • Korakianiti E., Rekkas D.M, Statistical thinking and knowledge management for quality-driven design and manufacturing in pharmaceuticals.Pharmaceutical Research 28,1465-79,2011.

  • Politis S.N., Rekkas D.M., The Evolution of the manufacturing science and the pharmaceutical industry.Pharmaceutical Research 28,1779-1781,2011.

  • Politis S.N., Rekkas D.M. Recent advantages in pulsatile oral drug delivery systems. Recent Patents on Drug Delivery and Formulation 7,2,87-98,2013.

  • Belotti S., Rossi A., Colombo P., Bettini R., Rekkas D., Politis S., Colombo G.,Balducci AG., Buttini F., Spray dried amikacin powder for inhalation in cystic fibrosis patients: A quality by design approach for product construction.International Journal of Pharmaceutics 471,1-2,507-515,2014.

  • Belotti S., Rossi A., Colombo P., Bettini R., Rekkas D., Politis S., Colombo G., Balducci AG., Buttini F., Spray-dried amikacin sulphate powder for inhalation in cystic fibrosis patients: The role of ethanol in particle formation.European Journal of Pharmaceutics and Biopharmaceutics 93,165-172,2015.

  • Politis S.N, Colomblo P, Colombo G, Rekkas D.M. Design of experiments (DoE) in pharmaceutical development.Drug Development and Industrial Pharmacy 43,6,889-901,2017.

  • Karatzas AA, Politis SN, Rekkas DM.Development of rapidly dissolving pellets within the Quality by Design approach.Drug Development and Industrial Pharmacy 43,5,770-779,2017.

  • Politis S.N, Rekkas D.M.Development of a fast, lean and agile direct pelletization process using experimental design techniques. Drug Development and Industrial Pharmacy 43,4,545-557, 2017.

  • The application of Quality by Design framework in the pharmaceutical development of dry powder inhalers, European Journal of Pharmaceutical Sciences, 2018,113, 64-76.

  • Exploring the oxidation and iron binding profile of a cyclodextrin encapsulated quercetin complex unveiled a controlled complex dissociation through a chemical stimulus, Biochimica et Biophysica Acta (BBA) - General Subjects, 2018, 1862, 9, 1913-1924.

  • Application of experimental design for the development of soft-capsules through a prilling, inverse gelation process. Journal of Drug Delivery Science and Technology. 2019, 49, 577-585.

  • Partial tablet coating by 3D printing. International Journal of  Pharmaceutics, 2020,581,119298.

  • Preparation and Biophysical Characterization of Quercetin Inclusion Complexes with β-Cyclodextrin Derivatives to be Formulated as Possible Nose-to-Brain Quercetin Delivery Systems. Molecular Pharmaceutics, 2020, 17, 11, 4241–4255.

  • Preparation, characterization and pharmacokinetics of an inhalable dry powder formulation of a new hydrophobic antibiotic derivative for the treatment of lung infections. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 33, 2: April 2, 2020.

Book

  • “Total Quality Management” T. Georgaki, K. Kouroupi, S. N. Politis and D.M. Rekkas, Athens 2010, Sideris Publications.

Patents

  • Rekkas D.M., Dallas P., Paterakis P., Hot melt direct pelletization process using a fluidized bed rotor granulator. GR1004855
  • Dallas P ., Rekkas D.M., Georgaki D. Pharmaceutical formulation for the transdermal administration of Ketotifen. GR1004995.
  • Rekkas D.M., Politis S.N. Hot melt direct pelletization for the production of modified release spheroids. GR20100100130
  • Rekkas D.M., Papamichail M., Politis S.N., Novel Pharmaceutical and Cosmetic Emulsions GR20120100449
  • Rekkas D.M., Politis S.N., Karatzas A., Manufacturing process for the preparation of fast disintegrating effervescent pellets, granules and or mixtures thereof GR1008366.
  • Buttini F, Rozou S, Rossi A, Zoumpliou V, Rekkas DM.,The application of Quality by Design framework in the pharmaceutical development of dry powder inhalers. Eur J Pharm Sci. 2017 Nov 23. pii: S0928-0987(17)30618-8. doi:10.1016/j.ejps.2017.10.042.

 

Contact Details

Dimitrios M.Rekkas

School of Pharmacy

University of Athens

Athens, 15771

Greece

Tel: +30-210-7274023

Fax: +30-210-7274027

E-mail: rekkas[at]pharm.uoa[dot]gr

PEOPLE: