ZOIDIS GRIGORIS

Associate Professor, Section of Pharmaceutical Chemistry

 Personal Website http://users.uoa.gr/~zoidis/  

 

Education

  • B.Sc. in Pharmaceutical Science, July 2000, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, NKUA. Grade: «Very Good». 
  • Master of Science (M.Sc.), (October 2002), Faculty of Pharmacy, NKUA, Department of Pharmaceutical Chemistry, Grade: "Excellent". 
  • Doctor of Philosophy(Ph. D), (September 2006), Faculty of Pharmacy, Department of Pharmaceutical Chemistry, NKUA. Grade: «Excellent». 
  • 2006-2009    Post-Doc fellow, with scholarship from the State Scholarship Foundation in the field of: Pharmaceutical Chemistry (Faculty of Pharmacy, Department of Pharmaceutical Chemistry, NKUA) under the supervision of    Professor George Fytas. 
  • 2009-2010      Post-Doc fellow in the field of: Pharmaceutical Chemistry (Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Bari, IT) under the supervision of Professor Angelo Carotti.
  • 09/2010-12/2011          Post-Doc fellow in the field of: Natural Product Synthesis (Faculty of Pharmacy, Department of Pharmacognosy and Natural Product Chemistry, NKUA) under the supervision of Professor LeandrosSkaltsounis.

Teaching

  • Undergraduate courses/labs: Pharmaceutical Chemistry (III) / Drug Synthesis Practicals, Introduction To Laboratory Practice.
  • Graduate courses: Advanced Pharmacochemistry I, Strategies For Organic Drug Synthesis and Design

Research topics

  • Design and synthesis of organic molecules with pharmacological activity [antiviral, antibacterial, trypanocidal,antineoplastic, and Central Nervous System (CNS)].
  • Structural modification of bioactive natural products and their derivatives aiming at the improvement of theirpotency.
  • Development of new synthetic methods. 

Distinctions

  • Undergraduate ScholarState Scholarships Foundation (IKY)
  • Postgraduate Scholar State Scholarships Foundation (IKY)(2000-2002)
  • PhD Scholar State Scholarships Foundation (IKY)(2002-2006)
  • Postdoctoral Scholar State Scholarships Foundation (IKY)(2007-2008)
  • 2019: 1st poster award in Medicinal Chemistry at the VIII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’19) in September 1-5, 2019, Athens, Greece.
  • 2019: 1st poster award in Medicinal Chemistry at the 11th Joint Meeting on Medicinal Chemistry 2019 (under the auspices of the European Federation for Medicinal Chemistry) in June 27–30, 2019 in Prague, Czech Republic.
  • 2019: 1st poster award in Medicinal Chemistry at the 32nd International Conference on Antiviral Research (ICAR), hosted by the International Society for Antiviral Research (ISAR) (Baltimore, USA, May 2019).
  • 2017: 1st poster award in Medicinal Chemistry at the 17th Hellenic Symposium on Medicinal Chemistry (HSMC-17) (Thessaloniki June 2017).
  • 2016: Selected to participate to the special issue “New Talents Europe” of MedChemComm. (MedChemComm Hot Articles collection, Front Page Cover Article).
  • 2015: Poster award in Medicinal Chemistry, selected for “shotgun” presentation, 28th International Conference on Antiviral Research (ICAR), Rome, Italy.  
  • 2014: 1st poster award in Medicinal Chemistry, 1st Int. Congress from Drug Discovery to Drug delivery 11-2014.
  • 2013: 1st poster award in Medicinal Chemistry at the 16th National Congress of Pharmaceutical Sciences.
  • 2012: Young Investigator award (researcher under 40) from the Association of Greek Chemists. Greek representative at the 4th EuCheMS Young Investigator Workshop in Vienna (2012).(http://investigator.ias.tuwien.ac.at/researchers.html)
  • 2012: 1st poster award in Medicinal Chemistry at the 1st Congress of Pharmaceutical Sciences.
  • 2012: Member of the editorial board of ‘Journal of Chemistry’ (http://www.hindawi.com/journals/chem/editors/medicinal.chemistry/)
  • 2010: Award from Elsevier Publishing Group for "Top-cited article" as published in Bioorganic & Medicinal Chemistry Letters 2003-2010.
  • 2004: 1st Prize for best scientific work: ‘Novel Aminoadamantane Derivatives with Pharmacological Activity’, European School of Medicinal Chemistry, Urbino, Italy, July 4-8 2004.

Recent publications 

  • Alaa R. S. Leila, Mai H. A. Mousa, EfseveiaFrakolaki, Niki Vassilaki, Ralf Bartenschlager, Grigoris Zoidis, Mohammad Abdel-Halim, Ashraf H. Abadi. Novel Symmetric Anti-HCV Agents: Synthesis, Antiviral Properties and Conformational Aspects of the Core Scaffold. ACS Omega, (2019), 4, 11440−11454.
  • Erofili Giannakopoulou, Vasiliki Pardali, EfseveiaFrakolaki, Vasileios Siozos, Vassilios Myrianthopoulos, Emmanuel Mikros, Martin C. Taylor, John M. Kelly, Niki Vassilaki and Grigoris Zoidis. Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species.Med. Chem. Commun., (2019), 10, 991–1006.
  • Tavis, J.E., Zoidis, G., Meyers, M.J., Murelli, R.P. Chemical Approaches to Inhibiting the Hepatitis B Virus Ribonuclease H, ACS Infectious Diseases, (2019), 5 (5), 655-658.
  • Fytas, G., Zoidis, G., Taylor, M.C., Kelly, J.M., Tsatsaroni, A., Tsotinis, A. Novel 2,6-diketopiperazine-derived acetohydroxamic acids as promising anti-Trypanosoma brucei agents. Future Medicinal Chemistry, Ahead of Print.
  • Giannakopoulou, E., Pardali, V., Skrettas, I., Zoidis, G. Transesterification instead of N-Alkylation: An Intriguing Reaction. ChemistrySelect, (2019), 4, 3195 –3198.
  • Ramsis, T.M. Abdel Karim, S.E., Vassilaki, N., Frakolaki, E., Kamal, A.A.M., Zoidis, G., Ahmed, N.S., Abadi, A.H. Expanding the chemical space of anti-HCV NS5A inhibitors by stereochemical exchange and peptidomimetic approaches. Archiv der Pharmazie, (2018), 351(7), 1800017.
  • Giannakopoulou, E., Pardali, V., Zoidis, G. Metal-chelating agents against viruses and parasites. Future Medicinal Chemistry, (2018), 10 (11), 1283-1285. 
  • Zoidis, G., Tsotinis, A., Tsatsaroni, A., Taylor, M.C., Kelly, J.M., Smirlis, D., Fytas, G. Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study. Chemical Biology and Drug Design (2018), 91 (2), 408-421.
  • Edwards, T.C.; Lomonosova, E.; Patel, J.A.; Li, Q.; Villa, J.A.; Gupta, A.K.; Morrison, L.A.; Bailly, F.; Cotelle, P.; Giannakopoulou, E.; Zoidis, G.; Tavis, J.E. Inhibition of hepatitis B virus replication by N-hydroxyisoquinolinediones and related polyoxygenated heterocycles, Antiviral Research (2017), 143, 205-217.  
  • Zoidis, Grigoris; Sosic, Alice; Da Ros, Silvia; Gatto, Barbara; Sissi, Claudia; Palluotto, Fausta; Carotti, Angelo; Catto, Marco, Indenocinnoline derivatives as G-​quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents, Bioorganic & Medicinal Chemistry (2017), 25(9), 2625-2634.

 

Contact 

Zoidis Grigoris

School of Pharmacy
Division of Pharmaceutical Chemistry
Panepistimiopolis- Zografou 157 71
Athens- Greece
Tel: 210 7274809, 2107274808  Fax: 210 727-4747
E-mail: zoidis[at]pharm.uoa[dot]gr, grigoris[at]zoidis[dot]com