Associate Professor, Section of Pharmaceutical Chemistry

Full CV

Education

• Degree: BS in Pharmacy, Department of Pharmacy, NKUoA, Greece.
• MSc in Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, NKUoA, Greece.
• PhD in Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, NKUoA, Greece.

Teaching

Undergraduate courses/labs:

• Co-teaching of the compulsory course “Οrganic Chemistry II”: second semester of the undergraduate program of the Department of Pharmacy (2021 – today).
• Co-teaching of the compulsory course “Inorganic Chemistry II”: second semester of the undergraduate program of the Department of Pharmacy (2015 – 2020).
• Co-teaching of the compulsory course “Pharmaceutical Chemistry I”: fifth semester of the undergraduate program of the Department of Pharmacy (2014 – today).
• Supervision of the laboratory course «Introduction in laboratory practice»: first year of the undergraduate program of the Department of Pharmacy (2014 – today).
• Supervision of the laboratory course «Drug Synthesis»: third year of the undergraduate program of the Department of Pharmacy (2014 – today).

Graduate course:

• Co-teaching of the compulsory course “Synthetical strategy of pharmaceutical molecules”: first semester of the postgraduate program of the Department of Pharmacy (2014 – today)
   

Research Interests

• Design and synthesis of classical cannabinoids (ABC-tricyclic compounds resembling the chemical structure of (-)-Δ9-THC) and non-classical cannabinoids (AC-bicyclic compounds) modulating CB1 and/or CB2 receptors, in the context of my Postdoctoral Research at CDD/Northeastern University, Boston, USA.
• Design and synthesis of adamantane derivatives with diverse pharmacological profiles, such as antiviral, antiproliferative/anticancer, anticonvulsive and/ antinociceptive, trypanocidal and antitubercular.
• Design and synthesis of small molecules with pharmacological activity against “Neglected Diseases”, such as trypanosomiasis, leishmaniasis and tuberculosis.
• Design and synthesis of indole derivatives with diverse pharmacological profiles, such as antitubercular and melatoninergic.

Recent Publications

• Synthesis and Testing of Analogs of the Tuberculosis Drug SQ109 Against Bacteria and Protozoa: Identification of Lead Compounds Against Mycobacterium abscessus and Malaria. M. Stampolaki, S. R. Malwal, N. Alvarez-Cabrera, Z. Gao, Μ. Moniruzzaman, S. O. Babii, N. Naziris, A. Rey-Cibati, Μ. Valladares-Delgado, A. L. Turcu, K-H Baek, T-N Phan, H. Lee, M. Alcaraz, S. Watson, M. van der Watt, D. Coertzen, N. Efstathiou, I. Stylianakis, M. Chountoulesi, C. M. Shoen, I. P. Papanastasiou, J. Brea, M. H. Cynamon, L-Μ Birkholtz, L. Kremer, J. H. No, S. Vázquez, G. Benaim, C. Demetzos, H. I. Zgurskaya, T. Dick, E. Oldfield, A. D. Kolocouris. ACS Infect. Dis. 2023, 9, 342-364. DOI:10.1021/acsinfecdis.2c00537
• Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists. I. P. Papanastasiou, M-O. Georgiadis, C. Iliopoulos-Tsoutsouvas, C. A. Paronis. C. A. Brust, N. K. Tran, L. Ji, X. Mab, J. T. Wood, N. Zvonok, F.Tong, L. M.Bohn, S. P. Nikas, A. Makriyannis, Eur.J.Med.Chem., 2022, 230, 114027, DOI: 10.1016/j.ejmech.2021.114027
• Biophysical Evaluation and In Vitro Controlled Release of Two Isomeric Adamantane Phenylalkylamines with Antiproliferative/Anticancer and Analgesic Activity.  M. Vlachou, A.-S. Foscolos, A. Siamidi, A. Syriopoulou, N. Georgiou, A. Dedeloudi, A. D. Tsiailanis, A. G. Tzakos, T. Mavromoustakos, I. P. Papanastasiou, Molecules, 2022, 27(1), 7. DOI: 10.3390/molecules27010007
• Maping the Melatonin Receptor.8. Selective MT2 Agonists derived from 5,6-dihydroindolo[2,1-a]isoquinolines and related systems. A. Tsotinis, P. A. Afroudakis, I. P. Papanastasiou, A. Sakellaropoulou, M. Boniakou, D. Komiotis, P. J. Garratt, P. Delagrange, A. Bocianowska-Zbrong, D. Sugden, ChemMedChem, 2022, e202200129. DOI:10.1002/cmdc.2022000129
• Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N Channels. C. Tzitzoglaki, K. McGuire, P. Lagarias, A. Konstantinidi, A. Hoffmann, N. A. Fokina, C. Ma, I. P. Papanastasiou, P. R. Schreiner, S. Vázquez, M. Schmidtke, J. Wang, D. D. Busath, A. Kolocouris, ACS Chem.Biol. 2020, 15 (9), 2331-2337, DOI: 10.1021/acschembio.0c00553
• Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei. M.-O. Georgiadis, V. Kourbeli, I. P. Papanastasiou, A. Tsotinis, M. C. Taylor, J. M. Kelly, RSC Med.Chem., 2020, 11(1), 72-84, DOI:10.1039/C9M D00478E 
• Synthesis, Biology, Computational Studies and in vitro Controlled Release of new Isoniazid-based Adamantane Derivative. A. Papageorgiou, A.-S. Foscolos, I. P. Papanastasiou, M. Vlachou, A. Siamidi, A. Vocat, S. T. Cole, T. F. Kellici, T. Mavromoustakos, A. Tsotinis, Future Med.Chem., 2019, 11(21), 2779-2802, DOI: 10.4155/fmc-2019-0038 
• Synthesis and evaluation of new nifurtimox-adamantane adducts with trypanocidal activity. A.-S. Foscolos, I. Papanastasiou, A. Tsotinis, M. C. Taylor, J. M. Kelly, ChemMedChem, 2019, 14, 1227-1231, DOI:10.1002/cmdc. 201900165
• Synthesis of diphenoxyadamantane alkylamines with pharmacological interest. M.-O. Georgiadis, V. Kourbeli, V. Ioannidou, E. Karakitsios, I. Papanastasiou, A. Tsotinis, D. Komiotis, A. Vocat, S. T. Cole, M. C. Taylor, J. M. Kelly, Bioorg.Med.Chem.Lett., 2019, 29(11), 1278-1281, DOI:10.1016/j.bmcl.2019. 04.010 
• Fluorine substituted methoxyphenylalkyl amides as potent melatonin receptor agonists. A. Tsotinis, R. Kompogennitaki, I. Papanastasiou, P. J. Garratt, A. Bocianowska, D. Sugden, Medchemcomm, 2019, 10(3), 460-464, DOI: 10.1039/C8MD00604K 

Contact

Postal address: Section of Pharmaceutical Chemistry,
Department of Pharmacy,
School of Health Sciences
National and Kapodistrian University of Athens,
Panepistimiopolis, 157 84
Athens, Greece
Tel. office: +30 210 727 4828
Tel. lab:  +30 210 727 4527, -4814
e-mail: papanastasiou@pharm.uoa.gr