Assοciate Professor, Section of Pharmaceutical Chemistry



  • B.S in Pharmacy. Department of Pharmacy, NKUA, Greece.
  • MsC in Medicinal Chemistry, NKUA, Greece.
  • PhD in Medicinal Chemistry, NKUA, Greece.
  • Post-Doc in Medicinal Chemistry, NKUA, Greece.
  • Post-Doc in Medicinal Chemistry, Groupe de Chimie Pharmaceutique, Universite΄ de Rouen, UFR Medecine-Pharmacie, France.


  • Undergraduate courses/labs: Special Topics in Organic Chemistry Organic Chemistry, Medical Chemistry Labs / Drug Synthesis Practicals
  • Graduate courses: Advanced Organic Synthesis I and II, Synthetical Strategy of Pharmaceutical Molecules 

Research topics

  • Development of new synthetic methods. 
  • Design and synthesis of organic molecules with pharmacological activity [antineoplastic, antiviral, antibacterial, trypanocidal and Central Nervous System (CNS)].
  • Structural modification of bioactive natural products and their derivatives aiming at the improvement of theirpotency.
  • Synthesis of Natural Compounds

Recent publications (2017-2019)

  • Kalampaliki, A. D.; Giannouli, V.; Skaltsounis, A.-L.; Kostakis, I. K. A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3, 4-Dihydroxyphenylglycol. Molecules2019, 24 (18), 3239.
  • Giannouli, V.; Lougiakis, N.; Kostakis, I. K.; Pouli, N.; Marakos, P.; Skaltsounis, A. L.; Horne, D. A.; Nam, S.; Gioti, K.; Tenta, R. Design and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity. Medicinal chemistry (Shariqah (United Arab Emirates))2019.
  • Giannopoulou, A. F.; Velentzas, A. D.; Konstantakou, E. G.; Avgeris, M.; Katarachia, S. A.; Papandreou, N. C.; Kalavros, N. I.; Mpakou, V. E.; Iconomidou, V.; Anastasiadou, E. Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer. International journal of molecular sciences2019, 20 (6), 1291
  • Diallinas, G.; Rafailidou, N.; Kalpaktsi, I.; Komianou, A. C.; Tsouvali, V.; Zantza, I.; Mikros, E.; Skaltsounis, L. A.; Kostakis, I. K. Hydroxytyrosol (HT) Analogues Act as Potent Antifungals by Direct Disruption of the Fungal Cell Membrane. Frontiers in Microbiology2018, 9, 2624.
  • Daniilides, K.; Lougiakis, N.; Evangelidis, T.; Kostakis, I. K.; Pouli, N.; Marakos, P.; Mikros, E.; Skaltsounis, A.-L.; Bach, S.; Baratte, B. Discovery of New Aminosubstituted Pyrrolopyrimidines with Antiproliferative Activity Against Breast Cancer Cells and Investigation of Their Effect Towards the PI3Kα Enzyme. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents)2017, 17 (7), 990–1002.



Kostakis Ioannis
School of Pharmacy
Division of Pharmaceutical Chemistry
Panepistimiopolis- Zografou 157 71
Athens- Greece
Tel: 210 7274212, 2107274520  Fax: 210 727-4747
E-mail: ikkostakis[at]pharm.uoa[dot]gr