Professor, Section of Pharmaceutical Chemistry




  • Degree in Pharmacy (1982) from the Department of Pharmacy, National and Kapodistrian University of Athens
  • PhD in Pharmaceutical Chemistry (1987) from the Department of Pharmacy, National and Kapodistrian University of Athens


Undergraduate courses/labs: 

  • Courses: "Pharmaceutical Chemistry II" to6th semester students of Pharmacy
  • Courses: "Pharmaceutical Chemistry IV" to 8th semester students of Pharmacy
  • Laboratory Courses: "Laboratory of Pharmaceutical Chemistry" to 5th-6th semester students of Pharmacy
  • Laboratory Courses: "Introduction to Laboratory Techniques" to 1th semester students of Pharmacy

Graduate courses:

  • Courses: “Advanced Medicinal Chemistry”

Research topics

  • design, synthesis and pharmacological activity evaluation of new compounds as potential cytotoxic and antiviral agents.

Recent publications

  • Synthesis and Pharmacological Evaluation of Novel Adenine−Hydrogen Sulfide Slow Release Hybrids Designed as MultitargetCardioprotective Agents. N. Lougiakis,A. Papapetropoulos,E. Gikas, S. Toumpas, P.  Efentakis,R. Wedmann,A. Zoga,Z. Zhou,E. K. Iliodromitis, A.-L. Skaltsounis,M. R. Filipovic, N. Pouli,P. Marakos, I. Andreadou J. Med. Chem. (2016) 59 (5), 1776–1790.
  • Novel pyrazolopyridine derivatives as potential angiogenesis inhibitors: Synthesis, biological evaluation and transcriptome-based mechanistic analysis. M. Michailidou, V. Giannouli, V. Kotsikoris, O. Papadodima, G. Kontogianni, I. K. Kostakis, N. Lougiakis, A. Chatziioannou, F. N. Kolisis, P. Marakos, N. Pouli, H. Loutrari Eur. J. Med. Chem. (2016), 121, 143-157.
  • The discovery of new cytotoxic pyrazolopyridine derivatives V. Giannouli, N. Lougiakis, I. K. Kostakis, N. Pouli, P. Marakos, A.-L. Skaltsounis, S. Nam, R. Jove, D. Horne, R. Tenta, H. Pratsinis, D. KletsasBioorg. Med. Chem. Lett., (2016) 26, 5229-5233.
  • Design and synthesis of purine analogues as highly specific ligands for FcyB, a ubiquitous fungal nucleobase transporter N. Lougiakis, E.-S. Gavriil, M. Kairis, G. Sioupouli, G. Lambrinidi, D. Benaki, E. Krypotou, E. Mikros, P. Marakos, N. Pouli, G. DiallinasBioorg. Med. Chem., (2016) 24, 5941-5952.
  • Robust, universal biomarker assay to detect senescent cells in biological specimens K. Evangelou, N. Lougiakis, S. V Rizou, A. Kotsinas, D. Kletsas, D. M. Espín, N. Kastrinakis, N. Pouli, P. Marakos, P. Townsend, M. Serrano, J. Bartek, V. G. Gorgoulis Aging Cell (2017), 16, 192-197.
  • Synthesis, docking study and kinase inhibitory activity of a number of new substituted pyrazolo[3,4-c]pyridines. M. Sklepari, N. Lougiakis, A. Papastathopoulos, N. Pouli, P. Marakos, V. Myrianthopoulos, T. Robert, S. Bach, E. Mikros, S. RuchauChem. Pharm. Bull. (2017), 65, 66-81.
  • Discovery of new aminosubstitutedpyrrolopyrimidines with antiproliferative activity against breast cancer cells and investigation of their effect towards the PI3Kα enzyme. K.   Daniilides, N. Lougiakis, T. Evangelidis, I.K. Kostakis, N. Pouli, P. Marakos, E. Mikros, A.-L. Skaltsounis, S. Bach, B. Baratte, S. Ruchaud, V. Karamani, A. Papafotika, S. Christoforidis, O. Argyros, E. Kouvari, C. Tamvakopoulos. Anticancer Agents Med. Chem., (2017), 17, 990-1002.
  • Synthesis and antiproliferative activity of new pyrazolo[3,4-c]pyridines. E.-S. Gavriil, N. Lougiakis, N. Pouli, P. Marakos, A.-L. Skaltsounis, S. Nam, R. Jove, D. Horne, K. Gioti, H. Pratsinis, D. Kletsas, R. Tenta. Medicinal Chemistry, (2017) 13(4), 365 - 374.
  • Design and Synthesis of Novel 7-Aminosubstituted pyrido[2,3-b]pyrazines Exhibiting Anti-breast Cancer Activity. O. Argyros §, N. Lougiakis §, E. Kouvari, A. Papafotika, C.P. Raptopoulou, V. Psycharis, S. Christoforidis, N. Pouli, P. Marakos, C. Tamvakopoulos. Eur. J. Med. Chem. (2017), 126, 954-968.
  • Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism N. Lougiakis, E. Frakolaki, P. Karmou, N. Pouli, P. Marakos, V. Madan, R. Bartenschlager, N. Vassilaki, Chemical Biology and Drug Design(2017)  90, 352-367.
  • Structure-activity relationships in fungal nucleobases transporters as dissected by the inhibitory effects of novel purine analoguesE.-S. Gavriil, S. Dimitrakis,G. Papadaki, S. Balaska, G. Lambrinidis, N. Lougiakis, P. Marakos, G.Diallinas, N. Pouli, E. Mikros. Eur. J. Med. Chem. (2018), 156, 240-251.
  • Design and synthesis of new substituted pyrazolopyridines with potent antiproliferative activity V. Giannouli, N. Lougiakis, I. K. Kostakis, N. Pouli, P. Marakos, A.-L. Skaltsounis, D. A. Horne, S. Nam, K. Gioti, R. Tenta. Med.Chem. (2019) in press.
  • Design, Synthesis and Biological Evaluation of Novel Substituted Purine Isosters as EGFR kinase inhibitors, with promising pharmacokinetic profile and in vivo efficacy. E.-S. Gavriil, A. Doukatas, Th. Karampelas, V. Myrianthopoulos, S. Dimitrakis, E. Mikros, P. Marakos, C.Tamvakopoulos, N. Pouli, Eur. J. Med. Chem. 176 (2019) 393-409.



Panagiotis Marakos

University of Athens
Faculty of Pharmacy
Department of Pharmaceutical Chemistry
157 71 Athens

Tel: 210 727-4830  Fax: 210 727-4747

E-mail: marakos[at]pharm.uoa[dot]gr