Associate Professor of Biopharmaceutics and Pharmacokinetics



  • B. Pharm. National and Kapodistrian University of Athens (1982)
  • PhD in Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens (1987)


  • Undergraduate courses/labs: Biopharmaceutics and Pharmacokinetics I, Biopharmaceutics and Pharmacokinetics II, Biopharmaceutics and Pharmacokinetics (Laboratory Work), Introduction to Laboratory Practice
  • Graduate courses/labs: Advanced Biopharmaceutics and Pharmacokinetics, Statistical Methods and Applications in Pharmaceutical Sciences, Industrial Pharmacy (Laboratory Work)

Research topics

  • Theoretical Pharmacokinetics (focus on Absorption analysis)
  • Bioequivalence (Absorption rate and extent metrics, Highly Variable Drugs, Narrow Therapeutic Index Drugs)
  • In vitro Dissolution and Permeability studies. In vivo absorption studies. In vitro-in vivo correlations


  • Research Fellow, IRT (Institut de Recherche Thérapeutique et Pharmacologique Clinique), Université René-Descartes, Hôpital Cochin, Paris (4/1989-1/1990)
  • Member of the Committee for Undergraduate Studies of the Faculty of Pharmacy, University of Athens (1996-1999)
  • Member of the Student Selection Committee of the postgraduate program in Clinical Pharmacy (1994-2002)
  • Member of the Student Selection Committee of the postgraduate program in Industrial Pharmacy (2013 – present)

Recent publications

  • On the leveling-off properties of the new bioequivalence limits for highly variable drugs of the EMA guideline. V. Karalis, M. Symillides, P. Macheras. Eur. J. Pharm. Sci., 44, 497-505 (2011)
  • Bioequivalence of highly variable drugs: A comparison of the newly proposed regulatory approaches by FDA and EMA. V. Karalis, M. Symillides, P. Macheras. Pharm. Res., 29, 1066-1077 (2012)
  • Exploring the relationships between scaled bioequivalence limits and within subject variability. M. Symillides, V. Karalis, P. Macheras. J. Pharm. Sci., 102, 296-301 (2013)
  • Gastrointestinal transfer: in vivo evaluation and implementation in in vitro and in silico predictive tools. B. Hens, J. Brouwers, B. Anneveld, M. Corsetti, M. Symillides, M. Vertzoni, C. Reppas, D.B. Turner, P. Augustijns. Eur. J. Pharm. Sci., 63, 233-242 (2014)
  • An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation. A. Kourentas, M. Vertzoni, N. Stavrinoudakis, A. Symillidis, J. Brouwers, P. Augustijns, C. Reppas, M. Symillides. Eur J Pharm Sci., 82, 106-114 (2016)
  • In-vitro evaluation of performance of solid immediate release dosage forms of weak bases in upper gastrointestinal lumen: experience with miconazole and clopidogrel salts. M. Dimopoulou, C.S. Mourouti, M. Vertzoni, M. Symillides, C. Reppas. J. Pharm. Pharmacol., 68, 579-587 (2016)
  • In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT. A. Kourentas, M. Vertzoni, M. Symillides, B. Hens, J. Brouwers, P. Augustijns, C. Reppas. Int J Pharm., 515, 352-358 (2016)
  • The BioGIT System: a Valuable In Vitro Tool to Assess the Impact of Dose and Formulation on Early Exposure to Low Solubility Drugs After Oral Administration. A. Kourentas, M. Vertzoni, V. Barmpatsalou, P. Augustijns, S. Beato, J. Butler, R. Holm, N. Ouwerkerk, J. Rosenberg, T. Tajiri, C. Tannergren, M. Symillides, C. Reppas. AAPS J., 20:71, 1-12 (2018)
  • The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations: a PEARRL review. C. Pentafragka, M. Symillides, M. McAllister, J. Dressman, M. Vertzoni, C. Reppas. J Pharm Pharmacol., 71, 557-580 (2019)
  • On the design of food effect studies in adults for extrapolating oral drug absorption data to infants: An exploratory study highlighting the importance of infant food. M. Statelova, K. Goumas, N. Fotaki, R. Holm, M. Symillides, C. Reppas, M. Vertzoni. AAPS J., in press (2019)


Postal address: Section Pharmaceutical Tecnology,
Department of Pharmacy,
National and Kapodistrian University of Athens,
Panepistimiopolis, 157 84
Athens, Greece
Tel.: (+30) 210 727 4675
Fax: (+30) 210 727 4027