Professor of Biopharmaceutics-Pharmacokinetics


  • Degree in Pharmacy (Aristotle University of Thessaloniki, AUTH) (1984)
  • PhD in Biopharmaceutics (Department of Pharmacy, National & Kapodistrian University of Athens, NKUoA) (1990)
  • Post-Doctoral training/research, Laboratory of Biopharmaceutics-Pharmacokinetics, Department of Pharmacy, NKUoA (1991-1999)


Undergraduate courses/labs: 

  • Biopharmaceutics & Pharmacokinetics I, 
  • Biopharmaceutics & Pharmacokinetics II, 
  • Laboratory in Biopharmaceutics & Pharmacokinetics

Graduate courses: 

  • Advanced Biopharmaceutics and Pharmacokinetics (MSc: Industrial Pharmacy/Clinical Pharmacy, Department of Pharmacy, NKUoA)
  • Applications of Statistics in Pharmaceutical Sciences (MSc: Industrial Pharmacy/Clinical Pharmacy/Cosmetology- Dermatopharmacology, Department of Pharmacy, NKUoA)
  • Special Courses in Industrial Pharmacy (MSc: Industrial Pharmacy, Department of Pharmacy, NKUoA)
  • Other routes of drug administration (MSc: NANOMED – ERASMUS MUNDUS JOINT MASTER DEGREE – EMJMD, Department of Pharmacy, University of Patras, Greece)

Research topics

  • Drug protein/macromolecules binding.
  • Use of cyclodextrins for the optimization of drug’s solubility, dissolution and absorption 
  • Development-formulation and in vitro and in vivo evaluation of novel dosage forms of bioactive compounds (synthetic or natural) with optimized absorption characteristics. 
  • Modeling of drug release, dissolution, absorption, distribution and elimination. 
  • Development and validation of analytical bioassays for the determination of drug levels in biological fluids and application to pre-clinical and clinical pharmacokinetic/pharmacodynamic studies.
  • Pre-clinical and clinical pharmacokinetic/pharmacodynamic studies.
  • Individualization of drug therapy by measuring plasma levels using pharmacokinetic parameters. 


  • PhD scholarship from the Hellenic State Scolarship Foundation, IKY (granded after examinations, 3-year scholarship, 1987-1990). 
  • President of the Controlled Release Society-Greek Chapter (2001-2006, 2011).
  • Director (elected) of the Section of Pharmaceutical Technology, Department of Pharmacy, UoA (since academic year 2015-2016).
  • President of the Internal Evaluation Committee of the Department of Pharmacy, NKUoA (since academic year 2017-2018).
  • Member of the Scientific Board for Drug Approvals of the National Organization for Medicines NOM (ΕΟF, since 2016).
  • Εuropean Medicines Agency-EMA, European expert – NOM representative (since 2016)

Recent publications

  • Ei. Christodoulou, I.A. Kechagia, N. Kostomitsopoulos, E. Balafas, E.Archontaki, A. Dokoumetzidis, G. Valsami. «Pharmacokinetics of silibinin after peros and intravenous administration to mice, as a HP-β-CD lyophilized product», Int. J. Pharm, 2015, 493:366-373.
  • Maria Siopi, Efthymios Neroutsos, Kalliopi Zisaki, Maria Gamaletsou, Maria Piroynaki, Panagiotis Tsirigotis, Nikolaos Sipsas, Aristides Dokoumetzidis, Evgenios Goussetis, Loukia Zerva, Georgia Valsami, and Joseph Meletiadis. "A bioassay for determining voriconazole serum levels in patients receiving combination therapy with echinocandins" Antimicrob. Agents Chemoth. 2016, 60(1):632-636. doi. org/10.1128/AAC.01688-15.
  • A. S Liossi, D. Ntountaniotis, T. F Kellici, M. V Chatziathanasiadou, G. Megariotis, M.Mania, J. Becker-Baldus, M. Kriechbaum, A. Krajnc, Ei. Christodoulou, C. Glaubitz, M. Rappolt, H. Amenitsch, G. Mali, D. N. Theodorou, G. Valsami, M. Pitsikalis, H. Iatrou, A. G. Tzakos, T. Mavromoustakos. Exploring the interactions of irbesartan and irbesartan-2-hydroxypropyl-beta-cyclodextrin complex with model membranes. BBA-Biomembranes, 1859(6):1089-1098, 2017
  • Ei. Christodoulou, N. Kadoglou, M. Stasinopoulou, O. Konstandi, Ch. Kenoutis, Z. Kakazanis, A. Rizakou, N. Kostomitsopoulos, G. Valsami. Crocus sativus L. aqueous extract reduces atherogenesis, increases atherosclerotic plaque stability and improves glucose control in diabetic atherosclerotic animals. Atherosclerosis, 2018, 268:207-214. (
  • D. A. Diamantis, S. Ramesova, Ch.s M. Chatzigiannis, I. Degano, P. S. Gerogianni, C. Karadima, S. Perikleous, D. Rekkas, I. P. Gerothanassis, D. Galaris, Th. Mavromoustakos, G. Valsami, R. Sokolova, A. G. Tzakos. Exploring the oxidation and iron binding profile of a cyclodextrin encapsulated quercetin complex unveiled a controlled complex dissociation through a chemical stimulus. BBA-General Subjects 1862: 1913–1924, 2018. ( 2018.06.006).
  • A. K. Tsaroucha, G. Valsami N. Kostomitsopoulos, M. Lambropoulou,  C. Anagnostopoulos,  Ei. Christodoulou,  E. Falidas,  A. Betsou,  Z. Kakazanis,  M. Pitiakoudis,  C. E Simopoulos. Silibinin Effect on Fas/FasL, HMGB1, and CD45 Expressions in a Rat Model Subjected to Liver Ischemia-Reperfusion Injury. J. Invest. Surg., 31:491-502, 2018, (
  • Ei. Christodoulou, Maria-Eleni Grafakou, H. Skaltsa, N. Kadoglou, N. Kostomitsopoulos, G. Valsami. Preparation, chemical characterization and determination of crocetin’s pharmacokinetics after oral and intravenous administration of Saffron (Crocus sativus L.) aqueous extract to C57/BL6J mice. J. Pharm. Pharmacol. 71 (2019), pp. 753–764. (http://doi.10.1111/jphp.13055) .
  • Athanasiadou I., Dokoumetzidis A., Voss Sven Ch., El Saftawy W., Valsami G., Georgakopoulos C.. Effect of hyperhydration on pharmacokinetic parameters and detection sensitivity of recombinant human erythropoietin in urine and serum doping control analysis. J. Pharm. Sci., 108 (2019) 2162-2172. ( .
  • L. Tiozzo Fasiolo, M. Dario Manniello, F. Bortolotti, F. Buttini, A. Rossi, F. Sonvico, P. Colombo, G. Valsami, G. Colombo and P. Russo. Flurbiprofen nasal powders for early inflammation in Alzheimer’s disease by nose-to-brain delivery. Journal of Drug Targeting, (2019) (  
  • Athanasiadou I, Vonaparti A, Saleh A, Mbeloug M, Dokoumetzidis A, Valsami G, Georgakopoulos C. Effect of hyperhydration on pharmacokinetics and detection of orally administered budesonide in doping control analysis. Scand. J. Med. Sci. Sports., 2019;29:1489–1500. (


Postal address: Section of Pharmaceutical Technology,
Department of Pharmacy,
National and Kapodistrian University of Athens,
Panepistimiopolis, 157 84
Athens, Greece
Tel.: +30(210) 727 4022
Fax: +30(210) 727 4027