HALABALAKI MARIA

Assistant Professor, Section of Pharmacognosy and Natural Products Chemistry

Full CV

 

Education

  • Degree in Pharmacy, Athens (1998)
  • MSc in Natural Products Chemistry,  Department of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens (2001)
  • PhD in Pharmacy, Department of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens (2005)

Teaching

  • Undergraduate courses: Special Courses on Pharmacognosy
  • Pharmacognosy II Labs, Introduction in Laboratory Practices 
  • Graduate courses: Spectroscopy I, Analysis I, Analysis II, Introduction to Good Laboratory Practice,  Bibliographic Search on Specialized Topics 

Research topics

  • Separation and purification of natural products using chromatographic techniques (VLC, MPLC, FCPC, HPLC). 
  • Structure elucidation of natural products via spectroscopic methods (UV-Vis, IR, CID, GC-MS, LC-MS, HRMS&HRMS/MS 1&2D NMR).
  • Development of quantitative and qualitative methods for the evaluation of plant extracts using chromatographic methods, HPLC-UV & LC-MS. Structure elucidation of natural products using LC-HRMSn techniques.
  • Development and application of analytical dereplication platform (LC/UPLC-DAD-HRMS&HRMSn) for the structure-oriented isolation and identification of bioactive natural products.
  • LC/MS and NMR based metabolomics approaches (metabolic profiling, fingerprinting) for dereplication purposes, quality control of foods and targeted discovery of bioactive natural products.
  • Development and application of LC-MS & GC-MS-based methodologies for the analysis (qualitatively and quantitatively) of human samples (plasma, urine, faeces). Investigation of the impact of diet on gut microflora and human health.

Distinctions

  • Egon Stahl in silver, a medal, a document and a monetary prize in order to recognize and promote young scientists working in the field of Pharmacognosy(Pharmaceutical Biology) and Analytical Phytochemistry. Award lecture “Integrated Metabolomic approaches in Natural Products Chemistry” media.wix.com/ugd/a5860a_8ea849ab51824774bc491415fd7a267b.pdf.63rd International Congress and Annual Meeting of the Society of for the Medicinal Plant and Natural Products Research – GA2015, 23rd – 27th August, 2015, Budapest, Hungary.
  • 62nd International Congress and Annual Meeting of the Society of for the Medicinal Plant and Natural Products Research – GA2014, 31st August – 4th September, 2045, Guimaraes, Portugal. Young scientists 1st award of the scientific work entitled “Quantitative study of two indirubin derivatives: 6-Bromoindirubin-3΄-oxime (6BIO) and 6-Bromoindirubin-3′-[O-(2-piperazine-1-ylethyl) oxime] (6BIO-pip) in mice plasma by LC-MS/MS. Application in a pharmacokinetic study”. J Tchoumtchoua, M Halabalaki, E Gikas, L Liu, R Joves, S Nam, LA Skaltsounis.
  • ’Irakleitos’’ 2000-2004 fellowship from National Ministry of Education for the implementation of doctoral research entitled “Phytochemical and Pharmacological study of phytoestrogens from genus Onobrychis as a source of phytoestrogens – Evaluation of the effect of O. ebenoides to osteoporosis”.

Recent publications

  • Johannes R Popp, Eleftherios A Petrakis, Apostolis Angelis, Maria Halabalaki, Günther K Bonn, Hermann Stuppner, Leandros A Skaltsounis. Rapid isolation of acidic cannabinoids from Cannabis sativa L. using pH-zone-refining centrifugal partition chromatography  Journal of Chromatography A,2019, 1599, 96-202
  • Eleni V Mikropoulou, Eleftherios A Petrakis, AikateriniArgyropoulou, Sofia Mitakou, Maria Halabalaki, Leandros A Skaltsounis. Quantification of bioactive lignans in sesame seeds using HPTLC densitometry: Comparative evaluation by HPLC-PDA. Food Chemistry, 2019,288, 1-7. 
  • Theodora Nikou, Vasiliki Liaki, Stathopoulos, Aimilia D Sklirou, Eleni N Tsakiri, Thomas Jakschitz, Günther Bonn, Ioannis P Trougakos, Maria Halabalaki, Leandros A Skaltsounis. Comparison survey of EVOO polyphenols and exploration of healthy aging-promoting properties of oleocanthal and oleacein. Food and Chemical Toxicology,2019, 125, 403-412.
  • Job Tchoumtchoua, Maria Halabalaki, EvangelosGikas, Anthony Tsarbopoulos, NikolettaFotaki, Lucy Liu, Sangkil Nam, Richard Jove, Leandros A Skaltsounis. Preliminary pharmacokinetic study of the anticancer 6BIO in mice using an UHPLC-MS/MS approach. Journal of Pharmaceutical and Biomedical Analysis, 2019, 164, 317-325
  • Simon Moosmang, Maria Pitscheider, Sonja Sturm, Christopher Seger, Herbert Tilg, Maria Halabalaki, HermannStuppner. Metabolomic analysis—Addressing NMR and LC-MS related problems in human feces sample preparation. Clinica Chimica Acta, 2019, 489, 169-176. 


Contact

Postal address: Section of Pharmacognosy and Natural Products Chemistry
Department of Pharmacy,
National and Kapodistrian University of Athens,
Panepistimiopolis, 157 71
Athens, Greece
Tel.: +30 210 7274781
Fax: +30 210 7274594
e-mail: mariahal@pharm.uoa.gr