Professor, Section of Pharmaceutical Chemistry

Research Group Webage

FULL CV

Education

• 1988:    Ph.D.        (Organic Chemistry)  Université  PARIS XI,  Orsay,  France
• 1984:    M. Sc.        (Organic Chemistry)  Université  PARIS XI,  Orsay,  France
• 1983:    Diploma     (Chemistry) University of Athens

Teaching

Undergraduate courses/labs: 

• Inorganic Pharmaceutical Chemistry
• Organic Spectroscopy
• Lab Work Pharmaceutical Chemistry
• Lab Work Pharmaceutical Analysis
• Drug Design

Graduate courses: 

• Advanced Medicinal Chemistry
• Organic Spectroscopy I
• Organic Spectroscopy II

Research topics
N.M.R. spectroscopy 
Molecular Structure Analysis of biologically active molecules (natural products peptides) and using and 
Structure Based Drug Design, Molecular Simulations, In Silico screening
NMR basedMetabolomics

Distinctions - Fellowships

• DAAD (Germany)            1996 
• Marie Curie Fellowship (European)    1994
• CIES (France)                1993
• Nat. Found. Sch. (ΙΚΥ Greece)        1985-88
• Invited Professor
• Invited Professor University of Vienna, March-May 2017 
• Invited Professor Institut de Chimie de Nice December 2013

Selected publications

• 1H NMR-MS-based heterocovariance as a drug discovery tool for fishing bioactive compounds out of a complex mixture of structural analogues. Grienke U, Foster PA, Zwirchmayr J, Tahir A, Rollinger JM, Mikros E. Sci Rep. (2019), 9:11113.  http://dx.doi.org/10.1038/s41598-019-47434-8
• Discovery and optimization of a selective ligand for the Switch/Sucrose Non-Fermenting-related bromodomains of Polybromo protein-1 by the use of virtual screening and hydration analysis." V Myrianthopoulos, N Gaboriaud-Kolar,; C Tallant,; M Hall, ; S Grigoriou,; P Brownlee,; O Fedorov, C Rogers,; D Heidenreich,  M Wanior, N Drosos, N Mexia, P Savitsky, T Bagratuni, E Kastritis, E Terpos, P Filippakopoulos, S Müller, A-L Skaltsounis, J Downs, S Knapp, E Mikros, J. Med. Chem., (2016), 59 8787–8803http://dx.doi.org/10.1021/acs.jmedchem.6b00355
• Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity Y Alguel, S Amillis, J Leung, G Lambrinidis, SCapaldi, N.J Scull, G Craven, S Iwata, A Armstrong, E Mikros, G Diallinas, A.D Cameron, Byrne, B. Nature Communications, (2016) dx.doi.org/10.1038/ncomms11336
• Heterocovariance Based Metabolomics as a Powerful Tool Accelerating Bioactive Natural Product Identification N Aligiannis M Halabalaki E Chaita, E Kouloura, A Argyropoulou, D Benaki, E Kalpoutzakis, A Angelis, K Stathopoulou, S Antoniou M Sani, V Krauth, O Werz, B Schutz, H Schafer, M Spraul, E Mikros, LA. SkaltsounisChemistry Select (2016), 1, 2531 – 2535 dx.doi.org/10.1002/slct.201600744
• H-1 NMR Metabonomic Analysis in Renal Cell Carcinoma: a Possible Diagnostic Tool Zira, AN; Theocharis, SE; Mitropoulos, D; Migdalis V; Mikros E. J. Prot. Res.  (2010), 9, 4038-4044 dx.doi.org/10.1021/pr100226m
• 1H NMR-Based Metabonomics for the Classification of Greek Wines According to Variety, Region and Vintage – Comparison with HPLC Data.  Anastasiadi, M; Zira, A; Magiatis, P; Haroutounian, S; Skaltsounis, AL; Mikros E; J. Agr. Food. Chem. (2009); 57; 11067-11074 dx.doi.org/10.1021/jf902137e
• An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins; Myrianthopoulos, V; Magiatis, P; Ferandin, Y; Skaltsounis, AL; Meijer, L; Mikros, E; J. Med. Chem.; (2007); 50; 4027-4037 dx.doi.org/10.1021/jm070077z
• Application of nuclear magnetic resonance spectroscopy combined with principal component analysis in detecting inborn errors of metabolism using blood spots: a metabonomic approach; Constantinou, MA; Papakonstantinou, E; Benaki, D; Spraul, M; Shulpis, K; Koupparis, MA; Mikros, E; Anal. Chim. Acta; (2004); 511; 303-312 dx.doi.org/10.1016/j.aca.2004.02.012

Contact

Professor Mikros Emmanuel
University of Athens
Faculty of Pharmacy
Department of Pharmaceutical Chemistry
Panepistimioupoli-Zografou
157 71 Athens
GREECE

Tel.: +30 210 7274813 Fax.: +30 210 7274747

e-mail: mikros[at]pharm.uoa[dot]gr