Associate Professor , Section of Pharmaceutical Chemistry



  • 1999: Degree in Pharmacy
  • 2001: MSc in Pharmaceutical Analysis
  • 2007: PhD in Pharmaceutical Analysis
  • 2007-2011: Post-Doctoral Research in Pharmaceutical Analysis


  • Undergraduate courses/Labs: Pharmaceutical Analysis Ι & ΙΙ, Laboratory of Pharmaceutical Analysis, Stability of Pharmaceutical Products, Introduction to laboratory techniques
  • Graduate courses: Advanced Pharmaceutical Analysis Ι & ΙΙ, Stability of Pharmaceutical Products, Statistics-Chemometrics

Research topics

  • Pharmaceutical Bioanalysis 
  • Drug analysis in formulations
  • Neonatal screening 
  • Dried Blood Spots
  • Mass Spectrometry
  • Chemometrics/Experimental Design (DoE)


List of recent publications

  • The significant role of Carnitine and Fatty acids during pregnancy, lactation ‎and ‎perinatal period. Nutritional support in specific groups of pregnant women Penelope D. Manta-Vogli, Kleopatra H. Schulpis, Yannis Dotsikas, Yannis L. ‎Loukas, Clin. Nutr. 39 (2020) 2337-2346‎
  • Hematocrit effect on dried blood spots in adults: a computational study and ‎theoretical considerations Chrysa Daousani, Vangelis Karalis, Anđelija Malenović, Yannis Dotsikas, Scand. J. Clin. Lab. Inv. 79 (2019) 325-333‎
  • Achievements in robotic automation of solvent extraction and related ‎approaches for bioanalysis of pharmaceuticals Michal Alexovič, Yannis Dotsikas, Peter Bober, Ján Sabo, J. Chromatogr. Β 1092 (2018) 402-421‎
  • Analysis of potential genotoxic impurities in rabeprazole active pharmaceutical ‎ingredient via Liquid Chromatography-tandem Mass Spectrometry, following ‎quality-by-design principles for method development Katerina Iliou, Andelija Malenović, Yannis L. Loukas, Yannis Dotsikas, J. Pharm. Biomed. Anal. 149 (2018) 410-418‎
  • Quantitation of brinzolamide in dried blood spots by a novel LC-QTOF-MS/MS ‎method Anargyros Foivas, Anđelija Malenović, Nađa Kostić, Marija Božić, Miroslav ‎‎Knežević, Yannis L. Loukas, Yannis Dotsikas, J. Pharm. Biomed. Anal. 119 (2016) 84-90
  • Liquid Chromatography coupled to Quadrupole-Time of Flight Tandem Mass ‎‎Spectrometry based Quantitative Structure-Retention Relationships of amino ‎acid ‎analogues derivatized via n-propyl chloroformate mediated reaction Nikolaos Kritikos, Anna Tsantili-Kakoulidou, Yannis L. Loukas, Yannis ‎Dotsikas, J. Chromatogr. A 1403 (2015) 70-80
  • Stepwise optimization approach for improving LC-MS/MS analysis of ‎zwitterionic antiepileptic drugs with implementation of Experimental Design ‎ Nađa Kostić, Yannis Dotsikas, Anđelija Malenović, Biljana Jančić–Stojanović, ‎Tijana Rakić, Darko Ivanović and Mirjana Medenica, J. Mass Spectrom. 48 (2013) 875-884‎
  • ‎Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: A worldwide collaborative project D. M. McHugh, C. A. Cameron, J. E. Abdenur, M. Abdulrahman, et al., Genet. Med. 13 (2011) 230-254
  • Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system A. Malenović, Y. Dotsikas, M. Mašković, B. Jančić–Stojanović, D. Ivanović and M. Medenica, Microchem. J. 99 (2011) 454-460
  • Turbulent flow and ternary column-switching on-line clean-up system for high-throughput quantification of risperidone and its main metabolite in plasma by LC-MS/MS. Application to a bioequivalence study C. Kousoulos, Y. Dotsikas and Y. L. Loukas, Talanta 72 (2007) 360-367
  • Employment of 4-(1-imidazolyl)phenol as a luminol signal enhancer in a competitive – type chemiluminescence immunoassay and its comparison with the conventional antigen – horseradish peroxidase conjugate based assay Y. Dotsikas and Y. L. Loukas, Anal. Chim. Acta 509 (2004) 103-109
  • Efficient Determination and Evaluation of Model Cyclodextrin Complex Binding Constants by Electrospray Mass Spectrometry Y. Dotsikas and Y. L. Loukas, J. Am. Soc. Mass Spectrom. 14 (2003) 1123-1129



Dotsikas Yannis (Ioannis)
School of Pharmacy
Division of Pharmaceutical Chemistry
Panepistimiopolis- Zografou 157 71
Athens- Greece
Tel: 210 727-4696  210 727-4039