KOUROUNAKIS ANGELIKI

Professor, Section of Pharmaceutical Chemistry

1990 B. Pharm, Aristotles University of Thessaloniki.
1995 PhD in Medicinal Chemistry, Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, USA.
1996-1997 Post-doctoral training (Dept. Medicinal Chemistry, Aristotles University of Thessaloniki).
1998-1999 Post-doctoral training ((Division of Medicinal Chemistry, University of Leiden, The Netherlands).

Undergraduate courses/labs: Molecular pharmacology, Drug metabolism, Basic Principles of Drug Design / Drug Synthesis.
Graduate courses: Biochemical and Molecular Pharmacology (Master's program of the Div. of Medicinal Chemistry), Molecular Pharmacology - Oxidative Stress (Master's program of the Div. of Pharmaceutical Technology / Cosmetology-Dermopharmacology)

Design, synthesis and pharmacological evaluation of bioactive molecules such as antiinflammatory, antiatherosclerosis and compounds for the prevention or treatment of Alzheimer’s disease – neuronal degeneration.
Emphasis is on multi-target drug design for multifactorial diseases such as atherosclerosis or neurodegeneration. Mechanism of action at the molecular level.
Molecular modeling and study of physicochemical properties. Structure-activity relationships.
Free radical pharmacochemistry – oxidative stress, prevention thereof. Drug Metabolism – effect of compounds on metabolic enzymes.

1994 Award for doctoral research presentation (7th Annual Excellence in Research Competition of the School of Pharmacy, University of Florida).
1998 Post doctoral scholarship/grant from the EU.
Visiting Scientist of LACDR (Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, University of Leiden)
2000 Post doctoral scholarship/grant from the EU.

Antihyperlipidemic morpholine derivatives with antioxidant activity: An investigation of the aromatic substitution. Eleni M. Ladopoulou, Alexios N. Matralis, Anastasios Nikitakis, Angeliki P. Kourounakis*. Bioorg Med Chem. 23(21):7015-7023 (2015).
Balancing Antioxidant, Hypolipidemic and Anti-inflammatory Activity in a Single Agent: The Example of 2-Hydroxy-2-Substituted Morpholine, 1,4-Benzoxazine and 1,4-Benzothiazine Derivatives as a Potential Therapeutic Approach against Atherosclerosis. Matralis AN, Bavavea EI, Incerpi S, Pedersen JZ, Kourounakis AP.* Curr Med Chem. 24:1214-1227 (2017).
Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity. Katselou, M.G., Matralis, A.N., Kourounakis, A.P.* Eur J Med Chem. 138:748-760 (2017).
Optimizing the Pharmacological Profile of New Bifunctional Antihyperlipidemic / Antioxidant Morpholine Derivatives. Alexios N. Matralis, and Angeliki P. Kourounakis* ACS Med. Chem. Lett. 10(1):98-104 (2019).
Morpholine as a privileged structure: a review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules. Angeliki P. Kourounakis*, Dimitrios Xanthopoulos and Ariadni Tzara. Med Res Rev. 1-44 (2019).

Angeliki Kourounakis

Department of Pharmaceutical Chemistry

School of Pharmacy

University of Athens

Panepistimiopolis, Zografou

GR – 157 71 Athens, GREECE

Tel.: (003210)7274818