Assistant Professor, Section of Pharmaceutical Chemistry

Education

• Degree in Pharmacy, Department of Pharmacy, National and Kapodistrian University of Athens, Greece, 2001.
• Msc in Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Greece, 2003.
• PhD in Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Greece, 2008.
• Postdoctoral researcher, Department of Pharmacy, National and Kapodistrian University of Athens, Greece, 2010.
• Postdoctoral researcher, Medicinal Chemistry Unit, School of Pharmacy, University of Camerino, Italy, 2011.
• Postdoctoral researcher, Department of Pharmacy, National and Kapodistrian University of Athens, Greece, 2012-2017.

Teaching

• Undergraduate courses/labs: Organic Chemistry I / Pharmaceutical Chemistry (Lab works), Introduction to Laboratory Practices.
• Graduate courses: Advanced Organic Chemistry I, Advanced Organic Chemistry II.

Research topics

• Design, synthesis and structure characterization of novel organic aromatic and heteroaromatic compounds with potential anticancer, antiviral and cardioprotective activity. Evaluation of the corresponding pharmacological data, in order to extract structure activity relationships.
• Synthesis of bioactive natural products analogues, with potential anticancer activity.
• Synthesis of novel biomarkers for the detection of cellular senescence.

Distinctions

• Scholarship as an undergraduate student from the Greek State Scholarships Foundation (IKY, 1998-2000).
• Scholarship as a postgraduate student from Operational Programme for Education and Initial Vocational Training (O.P. “Education”), through the Greek State Scholarships Foundation (IKY, 2001-2003).

Recent publications

• Structure-activity relationships in fungal nucleobases transporters as dissected by the inhibitory effects of novel purine analogues. E.-S. Gavriil, S. Dimitrakis, G. Papadaki, S. Balaska, G. Lambrinidis, N. Lougiakis, P. Marakos , G. Diallinas, N. Pouli, E. Mikros. Eur. J. Med. Chem. (2018), 156, 240-251.
• Design and Synthesis of Novel 7-Aminosubstituted pyrido[2,3-b]pyrazines Exhibiting Anti-breast Cancer Activity. O. Argyros, N. Lougiakis, E. Kouvari, A. Papafotika, C.P. Raptopoulou, V. Psycharis, S. Christoforidis, N. Pouli, P. Marakos, C. Tamvakopoulos. Eur. J. Med. Chem. (2017), 126, 954-968.
• Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism. N. Lougiakis, E. Frakolaki, P. Karmou, N. Pouli, P. Marakos, V. Madan, R. Bartenschlager, N. Vassilaki. Chem. Biol. Drug Des., (2017), 90, 352-367.
• Robust, universal biomarker assay to detect senescent cells in biological specimens. K. Evangelou, N. Lougiakis, S. V Rizou, A. Kotsinas, D. Kletsas, D. M. Espín, N. Kastrinakis, N. Pouli, P. Marakos, P. Townsend, M. Serrano, J. Bartek, V. G. Gorgoulis. Aging Cell (2017), 16, 192-197.
• Synthesis and Pharmacological Evaluation of Novel Adenine-Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents. N. Lougiakis, A. Papapetropoulos, E. Gikas, S. Toumpas, P. Efentakis, R. Wedmann, A. Zoga, Z. Zhou, E. K. Iliodromitis, A.-L. Skaltsounis, M.R. Filipovic, N. Pouli, P. Marakos, I. Andreadou. J. Med. Chem. (2016), 59, 1776-1790.
• Novel pyrazolopyridine derivatives as potential angiogenesis inhibitors: Synthesis, biological evaluation and transcriptome-based mechanistic analysis. M. Michailidou, V. Giannouli, V. Kotsikoris, O. Papadodima, G. Kontogianni, I. K. Kostakis, N. Lougiakis, A. Chatziioannou, F. N. Kolisis, P. Marakos, N. Pouli, H. Loutrari. Eur. J. Med. Chem. (2016), 121, 143-157.

Contact

Postal address: Section of Pharmaceutical Chemistry,
Department of Pharmacy,
National and Kapodistrian University of Athens,
Panepistimiopolis, 157 84
Athens, Greece
Tel.: +30(210) 727 4759
Fax: +30(210) 727 4747
e-mail: nlougiak@pharm.uoa.gr