Professor, Section of Pharmaceutical Chemistry

FULL CV

Education

• Degree in Pharmacy (1982) from the Department of Pharmacy, National and Kapodistrian University of Athens
• PhD in Pharmaceutical Chemistry (1988) from the Department of Pharmacy, National and Kapodistrian University of Athens

Teaching

Undergraduate courses/labs: 

• Courses: "Pharmaceutical Chemistry II" to6th semester students of Pharmacy
• Courses: "Pharmaceutical Chemistry IV" to 8th semester students of Pharmacy
• Laboratory Courses: "Laboratory of Pharmaceutical Analysis" to 7th-8th semester students of Pharmacy
• Laboratory Courses: "Introduction to Laboratory Techniques" to 1th semester students of Pharmacy

Graduate courses:

• Courses: “Advanced Medicinal Chemistry II”

Research topics

• Synthesis and evaluation of pharmacological activityof new compounds with potential anticancer and antiviral activity. Structure-activity relationships.

Recent publications

• Synthesis and Pharmacological Evaluation of Novel Adenine−Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents. N. Lougiakis,A. Papapetropoulos,E. Gikas, S. Toumpas, P.  Efentakis,R. Wedmann,A. Zoga,Z. Zhou,E. K. Iliodromitis, A.-L. Skaltsounis,M. R. Filipovic, N. Pouli,P. Marakos, I. Andreadou J. Med. Chem. (2016) 59 (5), 1776–1790.
• Novel pyrazolopyridine derivatives as potential angiogenesis inhibitors: Synthesis, biological evaluation and transcriptome-based mechanistic analysis. M. Michailidou, V. Giannouli, V. Kotsikoris, O. Papadodima, G. Kontogianni, I. K. Kostakis, N. Lougiakis, A. Chatziioannou, F. N. Kolisis, P. Marakos, N. Pouli, H. Loutrari Eur. J. Med. Chem. (2016), 121, 143-157.
• The discovery of new cytotoxic pyrazolopyridine derivatives V. Giannouli, N. Lougiakis, I. K. Kostakis, N. Pouli, P. Marakos, A.-L. Skaltsounis, S. Nam, R. Jove, D. Horne, R. Tenta, H. Pratsinis, D. Kletsas Bioorg. Med. Chem. Lett., (2016) 26, 5229-5233.
• Design and synthesis of purine analogues as highly specific ligands for FcyB, a ubiquitous fungal nucleobase transporter N. Lougiakis, E.-S. Gavriil, M. Kairis, G. Sioupouli, G. Lambrinidi, D. Benaki, E. Krypotou, E. Mikros, P. Marakos, N. Pouli, G. Diallinas Bioorg. Med. Chem., (2016) 24, 5941-5952.
• Robust, universal biomarker assay to detect senescent cells in biological specimens K. Evangelou, N. Lougiakis, S. V Rizou, A. Kotsinas, D. Kletsas, D. M. Espín, N. Kastrinakis, N. Pouli, P. Marakos, P. Townsend, M. Serrano, J. Bartek, V. G. Gorgoulis Aging Cell (2017), 16, 192-197.
• Synthesis, docking study and kinase inhibitory activity of a number of new substituted pyrazolo[3,4-c]pyridines. M. Sklepari, N. Lougiakis, A. Papastathopoulos, N. Pouli, P. Marakos, V. Myrianthopoulos, T. Robert, S. Bach, E. Mikros, S. Ruchau Chem. Pharm. Bull. (2017), 65, 66-81.
• Discovery of new aminosubstituted pyrrolopyrimidines with antiproliferative activity against breast cancer cells and investigation of their effect towards the PI3Kα enzyme. K.   Daniilides, N. Lougiakis, T. Evangelidis, I.K. Kostakis, N. Pouli, P. Marakos, E. Mikros, A.-L. Skaltsounis, S. Bach, B. Baratte, S. Ruchaud, V. Karamani, A. Papafotika, S. Christoforidis, O. Argyros, E. Kouvari, C. Tamvakopoulos. Anticancer Agents Med. Chem., (2017), 17, 990-1002.
• Synthesis and antiproliferative activity of new pyrazolo[3,4-c]pyridines. E.-S. Gavriil, N. Lougiakis, N. Pouli, P. Marakos, A.-L. Skaltsounis, S. Nam, R. Jove, D. Horne, K. Gioti, H. Pratsinis, D. Kletsas, R. Tenta. Medicinal Chemistry, (2017) 13(4), 365 - 374.
• Design and Synthesis of Novel 7-Aminosubstituted pyrido[2,3-b]pyrazines Exhibiting Anti-breast Cancer Activity. O. Argyros §, N. Lougiakis §, E. Kouvari, A. Papafotika, C.P. Raptopoulou, V. Psycharis, S. Christoforidis, N. Pouli, P. Marakos, C. Tamvakopoulos. Eur. J. Med. Chem. (2017), 126, 954-968.
• Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism N. Lougiakis, E. Frakolaki, P. Karmou, N. Pouli, P. Marakos, V. Madan, R. Bartenschlager, N. Vassilaki, Chemical Biology and Drug Design(2017)  90, 352-367.
• Structure-activity relationships in fungal nucleobases transporters as dissected by the inhibitory effects of novel purine analoguesE.-S. Gavriil, S. Dimitrakis,G. Papadaki, S. Balaska, G. Lambrinidis, N. Lougiakis, P. Marakos, G. Diallinas, N. Pouli, E. Mikros. Eur. J. Med. Chem. (2018), 156, 240-251.
• Design and synthesis of new substituted pyrazolopyridines with potent antiproliferative activity V. Giannouli, N. Lougiakis, I. K. Kostakis, N. Pouli, P. Marakos, A.-L. Skaltsounis, D. A. Horne, S. Nam, K. Gioti, R. Tenta. Med.Chem. (2019) in press.
• Design, Synthesis and Biological Evaluation of Novel Substituted Purine Isosters as EGFR kinase inhibitors, with promising pharmacokinetic profile and in vivo efficacy. E.-S. Gavriil, A. Doukatas, Th. Karampelas, V. Myrianthopoulos, S. Dimitrakis, E. Mikros, P. Marakos, C.Tamvakopoulos, N. Pouli, Eur. J. Med. Chem. 176 (2019) 393-409.

Contact

Nicole Pouli

Associate Professor

University of Athens
Faculty of Pharmacy
Department of Pharmaceutical Chemistry
Panepistimioupoli-Zografou
157 71 Athens
GREECE

Τel: 210 727-4185  Fax: 210 727-4747

E-mail: pouli[at]pharm.uoa[dot]gr