REPPAS CHRISTOS

Professor of Pharmaceutics

FULL CV  

Education

  • 1982, Pharmacy Degree, National and Kapodistrian University of Athens, Greece
  • 1982, Registered Pharmacist, Greece
  • 1984, Research training in Pharmaceutics, Department of Pharmacy, Chelsea College, University of London, UK
  • 1986, Doctor of Philosophy in Pharmaceutical Sciences (Field: Pharmaceutics), National and Kapodistrian University of Athens, Greece
  • 1990, Completion of Post-Doctoral training in Pharmaceutics, College of Pharmacy, The University of Michigan, USA


Teaching

Undergraduate / National and Kapodistrian University of Athens

  • 1989-2000, Laboratory in Pharmaceutical Technology
  • 1989-2011, Biopharmaceutics and Drug Disposition
  • Since 2006, Laboratory in Experimental Procedures in Biopharmaceutics – Pharmacokinetics
  • Since 2006, Laboratory in Biopharmaceutics – Pharmacokinetics
  • Since 2012, Biopharmaceutics – Pharmacokinetics I
  • Since 2012, Biopharmaceutics – Pharmacokinetics II

Undergraduate / Other

  • 2010-2018, Lectures in Statistical Inference in Pharmaceutical Sciences, Goethe University, Frankfurt/Main, Germany

Graduate / National and Kapodistrian University of Athens

  • Since 1995, Advanced Biopharmaceutics - Pharmacokinetics
  • Since 1995, Statistical methods and their applications in the Pharmaceutical Sciences
  • Since 2018, Laboratory in Industrial Pharmacy
  • Since 2018, Lectures in enabling oral drug delivery

Graduate / Other

  • 1995-2006, Lectures (focus: Biopharmaceutics) at an Socrates intensive course on new dosage forms and routes for administration of drugs, at various EU countries
  • Since 2013, Lectures (focus: Biopharmaceutics) at a summer school organized by the International Association of Physical Chemists, in Croatia
  • Since 2017, Lectures (focus: Biopharmaceutics) at Erasmus Mundus program with title Nanomed, University of Patras, Greece 


Research topics

  • Understanding the luminal environment of the human gastrointestinal tract
  • Effects of gastrointestinal physiology on intraluminal performance of xenobiotics
  • Formulation effects on intraluminal performance or oral drug products
  • Development of in vitro tests that are predictive of the intraluminal drug and drug products performance


Distinctions

  • Since 1993, member of Doctoral Evaluation Committees at Universities in the USA, Denmark, Finland, Germany
  • 2007, Invited co-editor of the special issue of Advanced Drug Delivery Reviews, volume 59, issue 7
  • 2010, Visiting Professor, Department of Pharmaceutical Technology, Goethe University, Germany
  • 2019, External evaluator for promotion of University Professors (Ireland)
  • 2019, Member of Editorial Board of The AAPS Journal, Journal of Pharmacy and Pharmacology, Biopharmaceutics and Drug Disposition, Journal of Drug Delivery Science & Technology


Recent publications

  • Partheniadis I, Vergkizi S, Lazari D, Reppas C, Nikolakakis I. Formulation, characterization and antimicrobial activity of tablets of essential oil prepared by compression of spray-dried powder. J Drug Del Sci Tech 50 (2019) 226–236.
  • Jankovic S, O'Dwyer PJ, Box KJ, Imanidis G, Reppas C, Kuentz M. Biphasic drug release testing coupled with diffusing wave spectroscopy for mechanistic understanding of solid dispersion performance. Eur J Pharm Sci. 2019: 137
  • Guimarães M, Statelova M, Holm R, Reppas C, Symilllides M, Vertzoni M, Fotaki 
  • N. Biopharmaceutical considerations in paediatrics with a view to the evaluation 
  • of orally administered drug products – a PEARRL review. J Pharm Pharmacol 2019;71:603-642.
  • O'Dwyer PJ, Litou C, Box KJ, Dressman JB, Kostewicz ES, Kuentz M, Reppas C. In vitro methods to assess drug precipitation in the fasted small intestine – a PEARRL review. J Pharm Pharmacol. 2019 Apr;71(4):536-556.
  • Pentafragka C, Symillides M, McAllister M, Dressman J, Vertzoni M, Reppas C. The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations – a PEARRL review. J Pharm Pharmacol. 2019 Apr;71(4):557-580.
  • Butler J, Hens B, Vertzoni M, Brouwers J, Berben P, Dressman J, Andreas CJ, Schaefer KJ, Mann J, McAllister M, Jamei M, Kostewicz E, Kesisoglou F, Langguth P, Minekus M, Müllertz A, Schilderink R, Koziolek M, Jedamzik P, Weitschies W, Reppas C, Augustijns P. In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration. Eur J Pharm Biopharm. 2019 Mar;136:70-83.
  • Koziolek M, Alcaro S, Augustijns P, Basit AW, Grimm M, Hens B, Hoad CL, Jedamzik P, Madla CM, Maliepaard M, Marciani L, Maruca A, Parrott N, Pávek P, Porter CJH, Reppas C, van Riet-Nales D, Rubbens J, Statelova M, Trevaskis NL, Valentová K, Vertzoni M, Čepo DV, Corsetti M. The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group. Eur J Pharm Sci. 2019 Jun 15;134:31-59.
  • Vertzoni M, Augustijns P, Grimm M, Koziolek M, Lemmens G, Parrott N, Pentafragka C, Reppas C, Rubbens J, Van Den Αbeele J, Vanuytsel T, Weitschies W, Wilson CG. Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review. Eur J Pharm Sci. 2019 Jun 15; 134:153-175.
  • Reppas C. Characterization of GI fluids content, viscosity, volume in dogs and humans: comparison under fasted and fed state conditions. Dissolution Technologies 41-42, August 2019
  • Reppas C, Vertzoni M. Estimation of Intraluminal Drug Solubility, in Solubility in Pharmaceutical Chemistry, C Saal and A. Nair (editors), DE GRUYTER, ISBN 978-3-11-054513-5, 2019
  • Statelova et al. On the design of food effect studies in adults for extrapolating oral drug 
  • absorption data to infants: An exploratory study highlighting the importance of infant food AAPS J. in press
  • Yamamoto Y, Kumagai H, Haneda M, Vertzoni M, Ouwerkerk N, Murayama D, Katakawa Y, Motonaga K, Reppas C, Tajiri T. The mechanism of solifenacin release from a pH-responsive ion-complex oral suspension in the fasted upper gastrointestinal lumen. Eur J Pharm Sci. in press
  • Kilic M, Avzoti A, Dressman J, Reppas C. Lipid-Based Oral Formulations, in In vitro Drug Release testing of Special Dosage Forms, N. Fotaki and S. Klein (editors), Wiley, in press


Contact

Postal address: Section of Pharmaceutical Technology, Department of Pharmacy,
National and Kapodistrian University of Athens, Panepistimiopolis, 157 84 Zografou, Athens, Greece
Tel.: (+30) 210 727 4678
Fax: (+30) 210 727 4027
e-mail: reppas@pharm.uoa.gr\