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VLACHOU MARILENA

Professor, Section of Pharmaceutical Technology

Full CV

 

 

 

Education

  • Degree: BSc in Pharmacy. National and Kapodistrian University of Athens (NKUoA), Greece
  • PhD in Pharmaceutical Technology, National and Kapodistrian University of Athens (NKUoA), Greece

Teaching

Undergraduate courses/labs 

  • Co-teaching of the compulsory course "Pharmaceutical Technology I" to the students of the 5th semester of the undergraduate programme of the Department of Pharmacy of the University of Athens (1994-present).
  • Co-teaching of the elective course "Modern Pharmaceutical Systems" to the students of the 8th semester of the undergraduate programme of the Department of Pharmacy of the University of Athens (2015-present).
  • Participation in the laboratory practicals of the course "Pharmaceutical Technology" (1994 - today, as a faculty member).
  • Supervision of the laboratory practicals of the undergraduate students of the School of Pharmacy, University of Rhode Island (U.R.I., U.S.A.) (1989).

Graduate courses

  • Co-teaching of the compulsory course "Physical Pharmacy" (Module: Industrial Pharmacy (1994 - today)).
  • Participation in the teaching of the seminar course "Cosmetology-Dermatopharmacology" (2016-).
  • Co-teaching of the compulsory course "Nanomedicine" (Module: Application of Nanotechnology in Medicine (2018 - ).
  • Joint organization and teaching of the compulsory course "Development of new drugs: Research, circulation and accessibility" (Module: Development of drug controlled release systems (2019 - ).

Research interests

  • Formulation and in vitro release studies of bioactive substances from topical formulations.
  • Controlling the efficacy and safety of formulations in skin disease therapies.
  • Modified release studies on novel pyrrolinoquinoline derivatives, with cytotoxic activity, from solid formulations.
  • Physicochemical properties of new excipients (Ulvans) and their application in the manufacture of solid pharmaceutical formulations, and of nanoparticulate substrates as active substance carriers for the study of their release.
  • Design and preparation of pharmaceutical formulations of bioactive compounds of diverse structure, via 3D-printing technology.
  • Application of Artificial Intelligence/Machine Learning, in predicting the release profile of bioactive substances from solid pharmaceutical formulations.

Distinctions

  • Designated Postgraduate Scholarship (Ε.Μ.Υ.) awarded by the Division of Pharmaceutical Technology (NKUoA).

Recent publications

  • C. Protopapa, A. Siamidi, A. Enelib, M. Elbadawi *, M. Vlachou *. Machine learning predicts direct compression drug release profiles and Kinetic Parameters. The AAPS Journal 27(5):124 (2025) DOI: 10.1208/s12248-025-01101-1
  • Christodoulou, A. Chondromatidou, N. D. Bikiaris, E. Balla, M. Vlachou, P. Barmpalexis, and D. N. Bikiaris,*. PLA-based electrospun nanofibrous mats towards application as antibiotic-carriers: processing parameters, fabrication and characterization. Pharmaceutics 17(5), 589 (2025)  DOI: 10.3390/pharmaceutics17050589
  • C. Protopapa, A. Siamidi, L. A. Junqueira, S. Kolibaka, H. Ahmed, J. Boateng, D. Douroumis,* and M. Vlachou*. 3D printed mucoadhesive bupropion hydrochloride buccal thin films using Liquid Crystal Display. JDDST (2025). DOI: 10.1016/j.jddst.2025.106873
  • C. Protopapa, A. Siamidi, L. A. Junqueira, A. G. Tabriz, D. Douroumis, M. Vlachou*. Sustained Release of 3D Printed Bupropion hydrochloride Tablets bearing Braille Imprints for the Visually Impaired. Int J Pharm. 663, (2024). DOI 10.1016/j.ijpharm.2024.124594
  • C. Protopapa, A.Siamidi, M. Vlachou*, D. Douroumis*.  In vitro release profile of hydrocortisone from 3D printed paediatric mini-tablets. Pharmaceutics, 16(3):385 (2024). DOI: 10.3390/pharmaceutics16030385
  • Apostolidi, C, Protopapa, A. Siamidi, M. Vlachou*, Y. Dotsikas* Dissolution assay of bupropion/naltrexone hydrochloride salts of bilayer composition tablets following the development and validation of a novel HPLC method Materials, 15(23), 8451 (2022). DOI:10.3390/ma15238451
  • D. Karalia, A. Siamidi, V. Karalis, M. Vlachou*. 3D-printed oral dosage forms: mechanical properties, computational approaches and applications. Pharmaceutics, 13, 1401 (2021). DOI: 10.3390/pharmaceutics13091401
  • M. Vlachou, V. Karalis*, An in Vitro—in Vivo Simulation Approach for the Prediction of Bioequivalence. Materials,14(3), 555; (2021). DOI: 10.3390/ma14030555
  • V. Karava, A. Siamidi, M. Vlachou*, E. Christodoulou, A. Zamboulis, D. Bikiaris, A. Kyritsis, P. Klonos*, Block Copolymers based on Poly (butylene adipate) and Poly (L-lactic acid) for Biomedical Applications: Synthesis, Structure and Thermo-Dynamical Studies. Soft Matter, 17, 2439-2453 (2020). DOI:10.1039/D0SM02053B
  • M. Vlachou*, S. Kikionis, A. Siamidi, S. Kyriakou, A. Tsotinis, E. Ioannou, V. Roussis* Development and Characterization of Eudragit®-based Electrospun Nanofibrous Mats and their Formulation into Nanofiber Tablets for the Modified Release of Furosemide. Pharmaceutics, 11(9), 480-93, (2019). DOI:10.3390/pharmaceutics11090480
  • M. Vlachou*, S. Kikionis, A. Siamidi, K. Tragou, E. Ioannou, V. Roussis, A. Tsotinis. Modified in vitro release of melatonin loaded in nanofibrous electrospun mats incorporated into mono-layered and three-layered tablets. J Pharm Sci 108(2), 970-976, (2019). DOI: 10.1016/j.xphs.2018.09.035
  • V. Papadopoulou, K. Kosmidis, M. Vlachou, P. Macheras. On the use of the Weibull function for the discernment of drug release mechanisms. Int J Pharm, 309, 44-50, (2006). DOI: 10.1016/j.ijpharm.2005.10.044 

Books/Book Chapters

  • G. Papaioannou, Κ.Ν. Demetzos, M. Vlachou-Konstantinidou: "Pharmaceutical Technology I: Principles of Pharmacy Physics and Nanotechnology" for the students of the 5th semester of the Department of Pharmacy (Parisianou Ed, Athens, 2007).
  • M. Vlachou-Konstantinidou, "Physical Pharmacy", Notes for the students of the Postgraduate Program (Athens, 2014-).
  • M. Vlachou, A. Samidi, Book chapter entitled “Melatonin modified release formulations” in C. M. Dragoi Ed. Melatonin - Molecular Biology, Clinical and Pharmaceutical Approaches. ISBN 978-953-51-6797-6, DOI: 10.5772/intechopen.78337 (2018).
  • M. Vlachou, A. Siamidi, S. Kyriakou, Book chapter entitled “Electrospinning and drug delivery” in Sajjad Haider and Adnan Haider Ed “Electrospinning and Electrospraying - Techniques and Applications”, ISBN 978-1-78984-700-0 DOI: 10.5772/intechopen.86181 (2019).
  • M. Vlachou, A. Siamidi, Book chapter entitled “Βiopolymers in drug delivery systems”, in C. Demetzos and N. Pippa Eds, “Nanomaterials for Clinical applications” ISBN: 9780128167052, Εlsevier 2019.
  • A. Siamidi, E. Tsintavi, D.M. Rekkas, M. Vlachou, Book chapter entitled “3D-Printed Modified-Release Tablets: A Review of the Recent Advances” in Usama Ahmad Ed “Pharmaceutical dosage forms” ISBN 978-1-83881-899-9 DOI: 10.5772/intechopen.90868 (2020).
  • M. Vlachou, A. Siamidi, C. Protopapa. Book chapter entitled “Extrusion-based 3D printing methods for oral solid dosage forms” in D. Lamprou. BOOK: “3D & 4D Printing Methods for Pharmaceutical Manufacturing and Personalised Drug Delivery: Opportunities & Challenges” 2023 (AAPS Introduction to Pharmaceutical Sciences series). Springer. ISSN (Print): 2522-834X.
  • M. Chountoulesi, C. Demetzos, M. Vlachou. Book chapter entitled “Modified-release drug delivery systems with emphasis in oral dosage forms’’in From Current to Future Trends in Pharmaceutical Technology, Paperback ISBN: 9780323911115 eBook ISBN: 9780323914390, Εlsevier 2023.
  • A. Karnaki, A. Siamidi, V. Karalis, N. Lagopati, N. Pippa, M. Vlachou. Book chapter entitled “Thermo-responsive hydrogels: current status and future perspectives” in Intechopen. Adriano De Oliveira Andrade (Ed) Book: Bioinspired Technology and Biomechanics 2024. DOI: 10.5772/intechopen.114986.
  • M. Vlachou, A. Siamidi C. Protopapa. Book chapter 2, entitled “3D printing Technologies for pharmaceutical applications” in D. Lamprou. Book: "Fundamentals and future trends of 3D printing in drug delivery” (20 November, 2024, Paperback ISBN: 9780443236457, eBook ISBN: 9780443236464).
  • I. Papoutsi, A. Siamidi, N. Lagopati, M. Gazouli, M. Vlachou*, N. Pippa* Book chapter entitled "Advancements in Omeprazole Formulations: from technological innovation to release strategies" in Latest Research on Drug Formulation Design DOI: 10.5772/intechopen.1008362
  • M. Vlachou, A. Siamidi. Book chapter entitled “Generic Drug Development & Biosimilars” in D. Lamprou. Book: "Taylor & Francis Group / CRC Press book titled Drug Delivery: from fundamentals to the future”, 2025, in press.


Contact

Postal address: Section of Pharmaceutical Technology,
Department of Pharmacy,
National and Kapodistrian University of Athens,
Panepistimiopolis, 157 84
Athens, Greece
Tel.: +30(210) 727 4674
e-mail: vlachou@pharm.uoa.gr

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