(Compulsory / Teaching hours per week: 9 / Assessment: laboratory exercises rating (40%), final written exam (60%) / Credits: 3)
Laboratory Tutorials:
G. Valsami (Professor), M. Symillidou (Associate Professor), M. Vertzoni (Assistant Professor)
Laboratory Exercises:
C. Reppas (Professor), S. Markantonis (Professor), G. Valsami (Professor), N. Drakoulis (Associate Professor), M. Symillidou (Associate Professor), M. Vertzoni (Assistant Professor), A. Dokoumetzidis (Assistant Professor), V. Karalis (Assistant Professor))
• Aqueous solubility of drug substances: Determination of the aqueous solubility of dipyridamole.
• Aqueous solubility of drug substances: Effect of β-cyclodextrin on the aqueous solubility of dipyridamole.
• In vitro dissolution of immediate release pharmaceutical products: Dissolution rate: Effect of pH on the dissolution rate of dipyridamole immediate release tablets,
• In vitro dissolution of immediate release pharmaceutical products: Comparison of dissolution curves using the similarity factor, f2.
• Protein binding of drugs: Study of the to the interaction of Cu++ ions with Bovine Serum Albumin (BSA).
• Protein binding of drugs: Application of Scatchard model for the determination of the binding parameters for the interaction of Cu++ with BSA.
• Analysis of in vitro and in vivo data: Calculation of basic pharmacokinetic parameters from in vivo data after per os administration. Evaluation of dissolution kinetics based on in vitro dissolution data.
• Analysis of in vitro and in vivo data: In vitro – in vivo correlation for per os administered drugs (Level A, B and C correlations).