Professor of Pharmaceutical and Organic Chemistry

FULL CV

Education

• Ph D in Synthetic Organic Chemistry. University of London, U.K. 
• BS major in Chemistry. The University of North Carolina at Charlotte, U.S.A. 
• Advanced Technology Centre, Athens, Greece - Two "O" levels: Physics, English. Two "A" levels: Chemistry, Mathematics.
  14th High School, Athens, Greece, High School Leaving Certificate

Teaching

• Undergraduate courses/labs:
  Organic Chemistry I, Pharmaceutical Chemistry I , Drug Synthesis Practicals
• Graduate courses:
  Application of the Retrosynthetic Methodology in the Preparation of Bioactive Compounds 

Research topics

• Development of new synthetic methods.
• Design and synthesis of organic molecules with pharmacological activity [antineoplastic, antiviral, antibacterial, trypanocidal and Central Nervous System (CNS)].
• Structural modification of bioactive natural products (e.g. melatonin) and their derivatives aiming at the improvement of their potency.

Distinctions

• 1985-1986 Franz Sondheimer Bursary
  Schilizzi Foundation Award  
• 1986-1987 Franz Sondheimer Bursary
• 1988           Permanent member, Convocation of the University of London
• 1994           NHRF/Royal Society Award
• 1995           NHRF/Royal Society Award

Patents

• Tsotinis Andrew, Kalogeropoulou Theodora, Roussakis Christos, Roussis Vassilios “1-(2-Alkoxy-5-carboxyphenyl)-α,β-unsaturated ketones, their preparation and application in therapeutics”. PCT International Patent, 1999, WO 99/54278.
• Calogeropoulou Theodora, Tsotinis Andrew, Souli Charikleia, Makriyannis Alexandros “GABAA modulating neurosteroids”.PCT International Patent, 2002, WO 02/053577 A2.
• Calogeropoulou Theodora, Tsotinis Andrew, Souli Charikleia, Makriyannis Alexandros “GABAA modulating neurosteroids”. United States Patent, 2006, 07064116.
• Andrew Tsotinis, Vassiliki Tsakalidou, Aikaterini Sakellaropoulou, Ioannis Papanastasiou “Side Chain Substituted Indolelalkyl Amides as Potent Melatonin Receptor Ligands”  US Patent Filing, 2025, 030-7677

Indicative publications 

• George Fytas, Grigoris Zoidis, Antonios Drakopoulos, Martin C Taylor, John M Kelly, Alexandra Tsatsaroni, Andrew Tsotinis “New Lipophilic Hydroxamates as Promising Trypanocidal Agents: Design,  ynthesis, SAR, and Conformational Behavior Studies” ACS Medicinal Chemistry Letters, 2024, 15(7), 1041-1048.
• Andrew Tsotinis, Pandelis A Afroudakis, Ioannis P Papanastasiou, Aikaterini Sakellaropoulou, Marina Boniakou, Dimitri Komiotis, Peter J Garratt, Philippe Delagrange, Alina Bocianowska‐Zbrog, David Sugden  “Mapping the Melatonin Receptor. 8. Selective MT2 Agonists Derived from 5,6‐Dihydroindolo[2,1‐a]isoquinolines and Related Systems” ChemMedChem, 2022, 17 (12), e202200129.
• Jennifer Sosa, Jennie Lipinski, Vassiliki Tsakalidou, Ioannis Papanastasiou, Aikaterini Sakellaropoulou, Andrew Tsotinis, Margarita Dubocovich “Selective MT2 Melatonin Receptor Antagonist Modulates Circadian Activity via Inhibition of the Endogenous Melatonin Signal in the East Bound Jet Lag Model” The FASEB Journal, 2021, 35 (https://doi.org/10.1096/fasebj.2021.35.S1.01911).
• Markos-Orestis Georgiadis, Violeta Kourbeli, Ioannis P Papanastasiou, Andrew Tsotinis, Martin C Taylor, John M Kelly “Synthesis and evaluation of novel 2, 4-disubstituted arylthiazoles against T.  brucei” RSC Medicinal Chemistry, 2020, 11 (1), 72-84.
• Stefanos Riganas, Ioannis Papanastasiou, George B. Foscolos, Andrew Tsotinis, Guillaume Serin, Jean-François Mirjolet, Kostas Dimas, Vassilios N. Kourafalos, Andreas Eleutheriades, Vassilios I. Moutsos, Humaira Khan, Stavroula Georgakopoulou, Angeliki Zaniou, Prassa Margarita, Maria Theodoropoulou, Athanasios Mantelas, Stavroula Pondiki, Alexandre Vamvakides
  “New adamantane phenylalkylamines with σ-receptor binding affinity and anticancer activity, associated with putative antagonism of neuropathic pain”. J. Med. Chem., 2012, 55, 10241-10261.
• Papanastasiou, A. Tsotinis, N. Kolocouris, S. Radhika Prathalingam, J. M. Kelly “Design, synthesis and trypanocidal activity of new aminoadamantane derivatives”. J. Med. Chem., 2008, 51, 1496-1500.
• Tsotinis, P.A. Afroudakis, K. Davidson, A. Prashar and D. Sugden “Design, synthesis and melatoninergic activity of new azido- and isothiocyanato-substituted indoles”.  J. Med. Chem., 2007, 50, 6436-6440.
• Tsotinis, A. Eleutheriades, L. Di Bari and G. Pescitelli “A New, Stereoselective, Ring Forming Reaction of 1,2-Ethanedithiol with N-Acylated Indoles”. J. Org. Chem., 2007, 72, 8928-8931.
• Tsotinis A, Vlachou M, Papahatjis DP, Calogeropoulou T, Nikas SP, Garratt PJ, Piccio V, Vonhoff S, Davidson K, Teh M-T, Sugden, D.
  “Mapping the Melatonin Receptor. 7. Subtype Selective Ligands Based on β-Substituted N-Acyl-5-methoxytryptamines and β-Substituted N-Acyl-5-methoxy-1-methyltryptamines”.  J. Med. Chem. 2006, 49, 3509-3519.
• Souli C, Avlonitis N, Calogeropoulou T, Tsotinis A, Maksay G, Biro T, Politi A, Mavromoustakos T, Makriyannis A, Reis H, Papadopoulos M.  “Novel 17beta-substituted conformationally constrained neurosteroids that modulate GABAA receptors”. J. Med. Chem., 2005, 48, 5203-14.
• Avlonitis N., Lekka E., Detsi A., Koufaki M., Calogeropoulou T., Scoulica E., Siapi E., Kyrikou I., Mavromoustakos T., Tsotinis A., Makriyannis A. “Design and synthesis of ring-bearing ether phospholipids possessing antileishmanial activity”. J. Med. Chem., 2003, 46, 755-767.
• Andrew Tsotinis, Andreas Eleutheriades, Katherine Hough and David Sugden “Design and synthesis of potent N1-substituted indole melatonin receptor agonists”. Chem. Commun., 2003, 382-383.

Books

• Andrew Tsotinis and Ioannis P. Papanastasiou Synthetic Melatonin Receptor Agonists and Antagonists IntechOpen Editions, 2020, DOI: 10.5772/intechopen.91424
• Pharmaceutical Chemistry Ι George Β.Foscolos, Andrew Tsotinis Symmetria Editions,  2011, ISBN-10: 969266309X
• Organic chemistry at a glance Authors: LAURENCE HARWOOD , JOHN MCKENDRICK , ROGER WHITEHEAD Editing: ANDREW TSOTINIS  Parisianou Editions, 2006, ISBN 9789603943877
• The mechanisms of chemical reactions at a glance Author: MARK MOLONEY Editing: ANDREW TSOTINIS Parisianou Editions, 2004, ISBN 9789603942450

Contact 

Professor Andrew Tsotinis
University of Athens
Faculty of Pharmacy
Department of Pharmaceutical Chemistry
Panepistimioupoli-Zografou
157 71 Athens
GREECE

Tel.: +30 210 7274812
Fax.: +30 210 7274747

e-mail: tsotinis@pharm.uoa.gr